Mechanisms for persistence of acute and chronic feline calicivirus infections in the face of vaccination

Niels C Pedersen, K. Floyd Hawkins

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

The study was concerned with possible reasons for the persistence of both acute and chronic feline calicivirus (FCV)-induced disease and sustained oral carriage in the field in the face of routine FCV immunization. It was concluded from this study that: 1) the original FCV-F9 strain, which is the basis of most live vaccines, still generates cross-reactive antibodies against almost all field strains in California, 2) vaccine strains derived from FCV-F9 may not be as broadly cross-protective as the parent strain, 3) whole inactivated FCV-2280 vaccine evokes high virus neutralizing antibody titers with an equally broad spectrum of cross-reactivity as FCV-F9, 4) all vaccine strains of FCV cause acute disease signs and protracted oral shedding when administered orally, 5) strains isolated from the mouth five to ten weeks following oral inoculation can differ from parental virus, usually appearing more vaccine resistant, 6) cats previously infected with field or vaccine strains develop much less severe acute illness when subsequently infected with heterologous FCV strains but are not protected against the chronic carrier state. Therefore, the persistence of FCV in the field cannot be explained solely by the emergence of vaccine resistant strains and vaccine virus itself may contribute to both acute and chronic infection and disease.

Original languageEnglish (US)
Pages (from-to)141-156
Number of pages16
JournalVeterinary Microbiology
Volume47
Issue number1-2
DOIs
StatePublished - 1995

Fingerprint

Caliciviridae Infections
Feline Calicivirus
Feline calicivirus
Vaccination
vaccination
Vaccines
vaccines
infection
mouth
Viruses
viruses
carrier state
Carrier State
acute course
live vaccines
Acute Disease
Neutralizing Antibodies
neutralizing antibodies
cross reaction
oral administration

Keywords

  • Calicivirus
  • Feline calicivirus

ASJC Scopus subject areas

  • Microbiology
  • veterinary(all)
  • Animal Science and Zoology

Cite this

Mechanisms for persistence of acute and chronic feline calicivirus infections in the face of vaccination. / Pedersen, Niels C; Floyd Hawkins, K.

In: Veterinary Microbiology, Vol. 47, No. 1-2, 1995, p. 141-156.

Research output: Contribution to journalArticle

@article{cf8fddb885fc4622a9476a3d0c7372e0,
title = "Mechanisms for persistence of acute and chronic feline calicivirus infections in the face of vaccination",
abstract = "The study was concerned with possible reasons for the persistence of both acute and chronic feline calicivirus (FCV)-induced disease and sustained oral carriage in the field in the face of routine FCV immunization. It was concluded from this study that: 1) the original FCV-F9 strain, which is the basis of most live vaccines, still generates cross-reactive antibodies against almost all field strains in California, 2) vaccine strains derived from FCV-F9 may not be as broadly cross-protective as the parent strain, 3) whole inactivated FCV-2280 vaccine evokes high virus neutralizing antibody titers with an equally broad spectrum of cross-reactivity as FCV-F9, 4) all vaccine strains of FCV cause acute disease signs and protracted oral shedding when administered orally, 5) strains isolated from the mouth five to ten weeks following oral inoculation can differ from parental virus, usually appearing more vaccine resistant, 6) cats previously infected with field or vaccine strains develop much less severe acute illness when subsequently infected with heterologous FCV strains but are not protected against the chronic carrier state. Therefore, the persistence of FCV in the field cannot be explained solely by the emergence of vaccine resistant strains and vaccine virus itself may contribute to both acute and chronic infection and disease.",
keywords = "Calicivirus, Feline calicivirus",
author = "Pedersen, {Niels C} and {Floyd Hawkins}, K.",
year = "1995",
doi = "10.1016/0378-1135(95)00101-F",
language = "English (US)",
volume = "47",
pages = "141--156",
journal = "Veterinary Microbiology",
issn = "0378-1135",
publisher = "Elsevier",
number = "1-2",

}

TY - JOUR

T1 - Mechanisms for persistence of acute and chronic feline calicivirus infections in the face of vaccination

AU - Pedersen, Niels C

AU - Floyd Hawkins, K.

PY - 1995

Y1 - 1995

N2 - The study was concerned with possible reasons for the persistence of both acute and chronic feline calicivirus (FCV)-induced disease and sustained oral carriage in the field in the face of routine FCV immunization. It was concluded from this study that: 1) the original FCV-F9 strain, which is the basis of most live vaccines, still generates cross-reactive antibodies against almost all field strains in California, 2) vaccine strains derived from FCV-F9 may not be as broadly cross-protective as the parent strain, 3) whole inactivated FCV-2280 vaccine evokes high virus neutralizing antibody titers with an equally broad spectrum of cross-reactivity as FCV-F9, 4) all vaccine strains of FCV cause acute disease signs and protracted oral shedding when administered orally, 5) strains isolated from the mouth five to ten weeks following oral inoculation can differ from parental virus, usually appearing more vaccine resistant, 6) cats previously infected with field or vaccine strains develop much less severe acute illness when subsequently infected with heterologous FCV strains but are not protected against the chronic carrier state. Therefore, the persistence of FCV in the field cannot be explained solely by the emergence of vaccine resistant strains and vaccine virus itself may contribute to both acute and chronic infection and disease.

AB - The study was concerned with possible reasons for the persistence of both acute and chronic feline calicivirus (FCV)-induced disease and sustained oral carriage in the field in the face of routine FCV immunization. It was concluded from this study that: 1) the original FCV-F9 strain, which is the basis of most live vaccines, still generates cross-reactive antibodies against almost all field strains in California, 2) vaccine strains derived from FCV-F9 may not be as broadly cross-protective as the parent strain, 3) whole inactivated FCV-2280 vaccine evokes high virus neutralizing antibody titers with an equally broad spectrum of cross-reactivity as FCV-F9, 4) all vaccine strains of FCV cause acute disease signs and protracted oral shedding when administered orally, 5) strains isolated from the mouth five to ten weeks following oral inoculation can differ from parental virus, usually appearing more vaccine resistant, 6) cats previously infected with field or vaccine strains develop much less severe acute illness when subsequently infected with heterologous FCV strains but are not protected against the chronic carrier state. Therefore, the persistence of FCV in the field cannot be explained solely by the emergence of vaccine resistant strains and vaccine virus itself may contribute to both acute and chronic infection and disease.

KW - Calicivirus

KW - Feline calicivirus

UR - http://www.scopus.com/inward/record.url?scp=0028808527&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028808527&partnerID=8YFLogxK

U2 - 10.1016/0378-1135(95)00101-F

DO - 10.1016/0378-1135(95)00101-F

M3 - Article

C2 - 8604546

AN - SCOPUS:0028808527

VL - 47

SP - 141

EP - 156

JO - Veterinary Microbiology

JF - Veterinary Microbiology

SN - 0378-1135

IS - 1-2

ER -