Mechanism of translation in eukaryotes

Nancy Villa, Christopher S. Fraser

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Abstract

Recent years have seen a tremendous advance in our understanding of the mechanism of protein synthesis in eukaryotic cells. Furthermore, our understanding of the role of translation in cancer development and progression, as well as its significance in clinical medicine has also greatly increased. The process of messenger RNA (mRNA) translation is comprised of four main stages: initiation, elongation, termination and ribosome recycling. Each stage is promoted by many different protein factors that interact with mRNA, transfer RNA (tRNA) and the 40S and 60S ribosomes to ensure an mRNA is accurately translated into protein. Here, we will describe the fundamental mechanisms involved in selection, recruitment, and translation of an mRNA by the eukaryotic ribosome with an emphasis on aspects most relevant to the theme of translation and cancer.

Original languageEnglish (US)
Title of host publicationTranslation and Its Regulation in Cancer Biology and Medicine
PublisherSpringer Netherlands
Pages7-37
Number of pages31
Volume9789401790789
ISBN (Print)9789401790789, 9401790779, 9789401790772
DOIs
StatePublished - Mar 1 2014

Keywords

  • eIF4E
  • Mechanism of translation
  • Protein synthesis
  • Ribosome
  • Ribosome recycling
  • Translation
  • Translation elongation
  • Translation factor
  • Translation initiation
  • Translation termination

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Villa, N., & Fraser, C. S. (2014). Mechanism of translation in eukaryotes. In Translation and Its Regulation in Cancer Biology and Medicine (Vol. 9789401790789, pp. 7-37). Springer Netherlands. https://doi.org/10.1007/978-94-017-9078-9_2