Mechanism of genital transmission of SIV: a hypothesis based on transmission studies and the location of SIV in the genital tract of chronically infected female rhesus macaques.

Chris J Miller, N. J. Alexander, P. Vogel, J. Anderson, P. A. Marx

Research output: Contribution to journalArticlepeer-review

95 Scopus citations

Abstract

To understand the biologic processes involved in transmission of HIV, we examined the genital tracts of chronically infected female macaques and localized SIV-infected cells. SIV was found in the genital tract of 12 of 16 animals and SIV-infected cells were located in the cervix and vagina. Inoculation of cell-free SIV into the blind vaginal pouch of hysterectomized macaques resulted in systemic infection. We propose a hypothesis to explain the early events in the genital transmission of SIV.

Original languageEnglish (US)
Pages (from-to)64-68
Number of pages5
JournalJournal of Medical Primatology
Volume21
Issue number2-3
StatePublished - Feb 1992

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

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