To understand the biologic processes involved in transmission of HIV, we examined the genital tracts of chronically infected female macaques and localized SIV-infected cells. SIV was found in the genital tract of 12 of 16 animals and SIV-infected cells were located in the cervix and vagina. Inoculation of cell-free SIV into the blind vaginal pouch of hysterectomized macaques resulted in systemic infection. We propose a hypothesis to explain the early events in the genital transmission of SIV.
|Original language||English (US)|
|Number of pages||5|
|Journal||Journal of Medical Primatology|
|State||Published - Feb 1992|
ASJC Scopus subject areas
- Animal Science and Zoology