Mechanical enterogenesis - A review

Rebecca Stark, James C.Y. Dunn

Research output: Contribution to journalReview article

Abstract

Mechanical enterogenesis is a novel method of lengthening pre-existing intestine with distractive force. The application of mechanical force on small intestine aims to induce cellular proliferation and ultimately increase bowel length. This has been investigated primarily for the treatment of short bowel syndrome (SBS). Research has been ongoing for well over a decade in this arena and a multitude of advances have been made, both in the understanding of the biology behind force induced cellular proliferation and in the basic mechanics of force delivery systems. Important experimental models have been developed for studying this phenomenon and the collaboration of engineers and medical researchers has lead to the design of several devices that successfully lengthen small intestine. This has catapulted the field forward and there may soon be a device suitable for medical use in humans. This review analyses the past, present and future of mechanical enterogenesis.

Original languageEnglish (US)
Pages (from-to)229-242
Number of pages14
JournalJournal of Healthcare Engineering
Volume3
Issue number2
DOIs
StatePublished - Jan 1 2012

Keywords

  • Distraction enterogenesis
  • Intestinal lengthening
  • Mechanical enterogenesis
  • Short bowel syndrome

ASJC Scopus subject areas

  • Biotechnology
  • Surgery
  • Biomedical Engineering
  • Health Informatics

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