Abstract
The joint is an organ and functions as a mechanical bearing created of biological materials. In the joint, as in all connective tissues, there is a relationship between mechanical factors and tissue behavior. Therefore, it is not surprising that joint health and osteoarthrosis are reflections of both mechanical and biological factors. Osteoarthrosis is not a disease, but organ failure caused initially by mechanical factors. The biological changes follow. There is no habitual pathophysiological cascade. Osteoarthrosis is best thought of not as a common final pathway, but as a common end stage. The hypotheses that in osteoarthrosis substructural disorganization of the matrix proceeds chondrocytic enzyme production, that impulsive loading is an essential factor in the progressive cartilage destruction, and that tidemark advancement and horizontal cartilage splitting are the primary mechanisms in progressive cartilage loss are discussed.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 12-21 |
| Number of pages | 10 |
| Journal | Seminars in Arthritis and Rheumatism |
| Volume | 21 |
| Issue number | 3 SUPPL. 2 |
| DOIs | |
| State | Published - 1991 |
| Externally published | Yes |
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Keywords
- articular cartilage loss
- degenerative joint disease
- joint damage
- Osteoarthrosis
ASJC Scopus subject areas
- Anesthesiology and Pain Medicine
- Orthopedics and Sports Medicine
- Rheumatology
Cite this
Mechanical determinants of osteoarthrosis. / Radin, E. L.; Burr, D. B.; Caterson, B.; Fyhrie, David P; Brown, T. D.; Boyd, R. D.
In: Seminars in Arthritis and Rheumatism, Vol. 21, No. 3 SUPPL. 2, 1991, p. 12-21.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Mechanical determinants of osteoarthrosis
AU - Radin, E. L.
AU - Burr, D. B.
AU - Caterson, B.
AU - Fyhrie, David P
AU - Brown, T. D.
AU - Boyd, R. D.
PY - 1991
Y1 - 1991
N2 - The joint is an organ and functions as a mechanical bearing created of biological materials. In the joint, as in all connective tissues, there is a relationship between mechanical factors and tissue behavior. Therefore, it is not surprising that joint health and osteoarthrosis are reflections of both mechanical and biological factors. Osteoarthrosis is not a disease, but organ failure caused initially by mechanical factors. The biological changes follow. There is no habitual pathophysiological cascade. Osteoarthrosis is best thought of not as a common final pathway, but as a common end stage. The hypotheses that in osteoarthrosis substructural disorganization of the matrix proceeds chondrocytic enzyme production, that impulsive loading is an essential factor in the progressive cartilage destruction, and that tidemark advancement and horizontal cartilage splitting are the primary mechanisms in progressive cartilage loss are discussed.
AB - The joint is an organ and functions as a mechanical bearing created of biological materials. In the joint, as in all connective tissues, there is a relationship between mechanical factors and tissue behavior. Therefore, it is not surprising that joint health and osteoarthrosis are reflections of both mechanical and biological factors. Osteoarthrosis is not a disease, but organ failure caused initially by mechanical factors. The biological changes follow. There is no habitual pathophysiological cascade. Osteoarthrosis is best thought of not as a common final pathway, but as a common end stage. The hypotheses that in osteoarthrosis substructural disorganization of the matrix proceeds chondrocytic enzyme production, that impulsive loading is an essential factor in the progressive cartilage destruction, and that tidemark advancement and horizontal cartilage splitting are the primary mechanisms in progressive cartilage loss are discussed.
KW - articular cartilage loss
KW - degenerative joint disease
KW - joint damage
KW - Osteoarthrosis
UR - http://www.scopus.com/inward/record.url?scp=0026320690&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026320690&partnerID=8YFLogxK
U2 - 10.1016/0049-0172(91)90036-Y
DO - 10.1016/0049-0172(91)90036-Y
M3 - Article
C2 - 1796301
AN - SCOPUS:0026320690
VL - 21
SP - 12
EP - 21
JO - Seminars in Arthritis and Rheumatism
JF - Seminars in Arthritis and Rheumatism
SN - 0049-0172
IS - 3 SUPPL. 2
ER -