Mechanical analysis of arterial plaques in native geometry with OCT wall motion analysis

Claire Robertson; Andrew E. Heidari; Zhongping Chen; Steven George

doi:10.1016/j.jbiomech.2013.11.010

Mechanical analysis of arterial plaques in native geometry with OCT wall motion analysis

Claire Robertson, Andrew E. Heidari, Zhongping Chen, Steven George

Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

The mechanical behavior of an atherosclerotic plaque may encode information about the type, composition, and vulnerability to rupture. Human arterial segments with varying plaque burden were analyzed ex vivo with optical coherence tomography (OCT) to determine plaque type and to determine compliance during pulsatile inflation in their native geometry. Calcifications and lipid filled plaques showed markedly different compliance when analyzed with OCT wall motion analysis. There was also a trend towards increased circumferential variation in arterial compliance with increasing plaque burden.

Original language	English (US)
Pages (from-to)	755-758
Number of pages	4
Journal	Journal of Biomechanics
Volume	47
Issue number	3
DOIs	https://doi.org/10.1016/j.jbiomech.2013.11.010
State	Published - Feb 7 2014

Keywords

Atherosclerotic plaque
Compliance
Optical coherence tomography

ASJC Scopus subject areas

Biophysics
Orthopedics and Sports Medicine
Biomedical Engineering
Rehabilitation

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abstract = "The mechanical behavior of an atherosclerotic plaque may encode information about the type, composition, and vulnerability to rupture. Human arterial segments with varying plaque burden were analyzed ex vivo with optical coherence tomography (OCT) to determine plaque type and to determine compliance during pulsatile inflation in their native geometry. Calcifications and lipid filled plaques showed markedly different compliance when analyzed with OCT wall motion analysis. There was also a trend towards increased circumferential variation in arterial compliance with increasing plaque burden.",

keywords = "Atherosclerotic plaque, Compliance, Optical coherence tomography",

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AU - Heidari, Andrew E.

AU - Chen, Zhongping

AU - George, Steven

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Y1 - 2014/2/7

N2 - The mechanical behavior of an atherosclerotic plaque may encode information about the type, composition, and vulnerability to rupture. Human arterial segments with varying plaque burden were analyzed ex vivo with optical coherence tomography (OCT) to determine plaque type and to determine compliance during pulsatile inflation in their native geometry. Calcifications and lipid filled plaques showed markedly different compliance when analyzed with OCT wall motion analysis. There was also a trend towards increased circumferential variation in arterial compliance with increasing plaque burden.

AB - The mechanical behavior of an atherosclerotic plaque may encode information about the type, composition, and vulnerability to rupture. Human arterial segments with varying plaque burden were analyzed ex vivo with optical coherence tomography (OCT) to determine plaque type and to determine compliance during pulsatile inflation in their native geometry. Calcifications and lipid filled plaques showed markedly different compliance when analyzed with OCT wall motion analysis. There was also a trend towards increased circumferential variation in arterial compliance with increasing plaque burden.

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KW - Compliance

KW - Optical coherence tomography

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Mechanical analysis of arterial plaques in native geometry with OCT wall motion analysis

Abstract

Keywords

ASJC Scopus subject areas

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