Abstract
The mechanical behavior of an atherosclerotic plaque may encode information about the type, composition, and vulnerability to rupture. Human arterial segments with varying plaque burden were analyzed ex vivo with optical coherence tomography (OCT) to determine plaque type and to determine compliance during pulsatile inflation in their native geometry. Calcifications and lipid filled plaques showed markedly different compliance when analyzed with OCT wall motion analysis. There was also a trend towards increased circumferential variation in arterial compliance with increasing plaque burden.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 755-758 |
| Number of pages | 4 |
| Journal | Journal of Biomechanics |
| Volume | 47 |
| Issue number | 3 |
| DOIs | |
| State | Published - Feb 7 2014 |
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Keywords
- Atherosclerotic plaque
- Compliance
- Optical coherence tomography
ASJC Scopus subject areas
- Biophysics
- Orthopedics and Sports Medicine
- Biomedical Engineering
- Rehabilitation
Cite this
Mechanical analysis of arterial plaques in native geometry with OCT wall motion analysis. / Robertson, Claire; Heidari, Andrew E.; Chen, Zhongping; George, Steven.
In: Journal of Biomechanics, Vol. 47, No. 3, 07.02.2014, p. 755-758.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Mechanical analysis of arterial plaques in native geometry with OCT wall motion analysis
AU - Robertson, Claire
AU - Heidari, Andrew E.
AU - Chen, Zhongping
AU - George, Steven
PY - 2014/2/7
Y1 - 2014/2/7
N2 - The mechanical behavior of an atherosclerotic plaque may encode information about the type, composition, and vulnerability to rupture. Human arterial segments with varying plaque burden were analyzed ex vivo with optical coherence tomography (OCT) to determine plaque type and to determine compliance during pulsatile inflation in their native geometry. Calcifications and lipid filled plaques showed markedly different compliance when analyzed with OCT wall motion analysis. There was also a trend towards increased circumferential variation in arterial compliance with increasing plaque burden.
AB - The mechanical behavior of an atherosclerotic plaque may encode information about the type, composition, and vulnerability to rupture. Human arterial segments with varying plaque burden were analyzed ex vivo with optical coherence tomography (OCT) to determine plaque type and to determine compliance during pulsatile inflation in their native geometry. Calcifications and lipid filled plaques showed markedly different compliance when analyzed with OCT wall motion analysis. There was also a trend towards increased circumferential variation in arterial compliance with increasing plaque burden.
KW - Atherosclerotic plaque
KW - Compliance
KW - Optical coherence tomography
UR - http://www.scopus.com/inward/record.url?scp=84892519351&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84892519351&partnerID=8YFLogxK
U2 - 10.1016/j.jbiomech.2013.11.010
DO - 10.1016/j.jbiomech.2013.11.010
M3 - Article
C2 - 24388166
AN - SCOPUS:84892519351
VL - 47
SP - 755
EP - 758
JO - Journal of Biomechanics
JF - Journal of Biomechanics
SN - 0021-9290
IS - 3
ER -