Mecamylamine reduces nicotine cross-desensitization of trigeminal caudalis neuronal responses to oral chemical irritation

Christopher T. Simons, Satoko Sudo, Makoto Sudo, Earl Carstens

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

We investigated the role of neuronal nicotinic acetylcholine receptors (nAChRs) in nicotine cross-desensitization of chemonociceptive responses of trigeminal subnucleus caudalis (Vc) neurons in rats. Vc responses to lingually applied pentanoic acid were significantly reduced following nicotine, and this was prevented when the nAChR antagonist mecamylamine was applied before or after nicotine. A peripheral site of nicotine cross-desensitization is suggested via a nAChR-mediated reduction in acidic excitation of lingual nociceptors that project to Vc.

Original languageEnglish (US)
Pages (from-to)249-253
Number of pages5
JournalBrain Research
Volume991
Issue number1-2
DOIs
StatePublished - Nov 21 2003

Fingerprint

Mecamylamine
Nicotine
Pentanoic Acids
Nociceptors
Nicotinic Receptors
Tongue
Neurons

Keywords

  • Mecamylamine
  • Nicotine cross-desensitization
  • Oral chemical irritation
  • Trigeminal caudalis neuronal response

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Mecamylamine reduces nicotine cross-desensitization of trigeminal caudalis neuronal responses to oral chemical irritation. / Simons, Christopher T.; Sudo, Satoko; Sudo, Makoto; Carstens, Earl.

In: Brain Research, Vol. 991, No. 1-2, 21.11.2003, p. 249-253.

Research output: Contribution to journalArticle

Simons, Christopher T. ; Sudo, Satoko ; Sudo, Makoto ; Carstens, Earl. / Mecamylamine reduces nicotine cross-desensitization of trigeminal caudalis neuronal responses to oral chemical irritation. In: Brain Research. 2003 ; Vol. 991, No. 1-2. pp. 249-253.
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