Measuring regional changes in the diastolic deformation of the left ventricle of SHR rats using microPET technology and hyperelastic warping

Alexander I. Veress, Jeffrey A. Weiss, Ronald H. Huesman, Bryan W. Reutter, Scott E. Taylor, Arek Sitek, Bing Feng, Yongfeng Yang, Grant T. Gullberg

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

The objective of this research was to assess applicability of a technique known as hyperelastic warping for the measurement of local strains in the left ventricle (LV) directly from microPET image data sets. The technique uses differences in image intensities between template (reference) and target (loaded) image data sets to generate a body force that deforms a finite element (FE) representation of the template so that it registers with the target images. For validation, the template image was defined as the end-systolic microPET image data set from a Wistar Kyoto (WKY) rat. The target image was created by mapping the template image using the deformation results obtained from a FE model of diastolic filling. Regression analysis revealed highly significant correlations between the simulated forward FE solution and image derived warping predictions for fiber stretch (R 2 = 0.96), circumferential strain (R 2 = 0.96), radial strain (R 2 = 0.93), and longitudinal strain (R 2 = 0.76) (p < 0.001 for all cases). The technology was applied to microPET image data of two spontaneously hypertensive rats (SHR) and a WKY control. Regional analysis revealed that, the lateral freewall in the SHR subjects showed the greatest deformation compared with the other wall segments. This work indicates that warping can accurately predict the strain distributions during diastole from the analysis of microPET data sets.

Original languageEnglish (US)
Pages (from-to)1104-1117
Number of pages14
JournalAnnals of Biomedical Engineering
Volume36
Issue number7
DOIs
StatePublished - Jul 2008

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Rats
Regression analysis
Fibers

Keywords

  • Deformation
  • Diastole
  • Heart model
  • Hypertension
  • Hypertrophy
  • Mechanics
  • Metabolism
  • microPET
  • SHR model

ASJC Scopus subject areas

  • Biomedical Engineering

Cite this

Measuring regional changes in the diastolic deformation of the left ventricle of SHR rats using microPET technology and hyperelastic warping. / Veress, Alexander I.; Weiss, Jeffrey A.; Huesman, Ronald H.; Reutter, Bryan W.; Taylor, Scott E.; Sitek, Arek; Feng, Bing; Yang, Yongfeng; Gullberg, Grant T.

In: Annals of Biomedical Engineering, Vol. 36, No. 7, 07.2008, p. 1104-1117.

Research output: Contribution to journalArticle

Veress, AI, Weiss, JA, Huesman, RH, Reutter, BW, Taylor, SE, Sitek, A, Feng, B, Yang, Y & Gullberg, GT 2008, 'Measuring regional changes in the diastolic deformation of the left ventricle of SHR rats using microPET technology and hyperelastic warping', Annals of Biomedical Engineering, vol. 36, no. 7, pp. 1104-1117. https://doi.org/10.1007/s10439-008-9497-9
Veress, Alexander I. ; Weiss, Jeffrey A. ; Huesman, Ronald H. ; Reutter, Bryan W. ; Taylor, Scott E. ; Sitek, Arek ; Feng, Bing ; Yang, Yongfeng ; Gullberg, Grant T. / Measuring regional changes in the diastolic deformation of the left ventricle of SHR rats using microPET technology and hyperelastic warping. In: Annals of Biomedical Engineering. 2008 ; Vol. 36, No. 7. pp. 1104-1117.
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