Measuring brain chemistry using genetically encoded fluorescent sensors

Alessio Andreoni, Carolyn M.O. Davis, Lin Tian

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations


To understand the precise roles of chemical messengers in the brain for communication, we need tools to measure the concentration and release events of neurotransmitters and neuromodulators with great precision. Fluorescent protein–based biosensors with high molecular specificity have been recently developed for direct, optical recording of brain chemistry. Here, we discuss the engineering and applications of the most recently developed genetically encoded neuromodulator sensors for in vivo studies.

Original languageEnglish (US)
Pages (from-to)59-67
Number of pages9
JournalCurrent Opinion in Biomedical Engineering
StatePublished - Dec 2019


  • Fluorescent protein
  • Genetically encoded fluorescent indicators
  • GPCRs
  • Molecular imaging
  • Neuromodulators
  • Neurotransmitter

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials
  • Bioengineering
  • Medicine (miscellaneous)


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