TY - JOUR
T1 - Measures of postprandial lipoproteins are not associated with coronary artery disease in patients with type 2 diabetes mellitus
AU - Reyes-Soffer, Gissette
AU - Holleran, Steve
AU - Karmally, Wahida
AU - Ngai, Colleen I.
AU - Chen, Niem Tzu
AU - Torres, Margarita
AU - Ramakrishnan, Rajasekhar
AU - Blaner, William S.
AU - Berglund, Lars
AU - Ginsberg, Henry N.
AU - Tuck, Catherine
PY - 2009
Y1 - 2009
N2 - Individuals with type 2 diabetes mellitus (DM) characteristically have elevated fasting and postprandial (PP) plasma triglycerides (TG). Previous case-control studies indicated that PPTG levels predict the presence of coronary artery disease (CAD) in people without DM; however, the data for patients with DM are conflicting. Therefore, we conducted a case-control study in DM individuals, 84 with (+) and 80 without (-) CAD. Our hypothesis was that DM individuals with or without CAD would have similar PPTG levels, but CAD+ individuals would have more small d<1.006 g/L lipoprotein particles. Several markers of PP lipid metabolism were measured over 10 h after a fat load. PP lipoprotein size and particle number were also determined. There was no significant difference in any measure of PP lipid metabolism between CAD+ and CAD-, except for apoB48, which was actually higher in CAD-. We followed 69 CAD- participants for a mean 8.7 years; 33 remained free of any cardiovascular event. There were no PP differences at baseline between these 33 who remained CAD- and either the 36 original CAD- who subsequently developed CAD or the original CAD+ group. PP measurements of TG-rich lipoproteins do not predict the presence of CAD in individuals with DM.
AB - Individuals with type 2 diabetes mellitus (DM) characteristically have elevated fasting and postprandial (PP) plasma triglycerides (TG). Previous case-control studies indicated that PPTG levels predict the presence of coronary artery disease (CAD) in people without DM; however, the data for patients with DM are conflicting. Therefore, we conducted a case-control study in DM individuals, 84 with (+) and 80 without (-) CAD. Our hypothesis was that DM individuals with or without CAD would have similar PPTG levels, but CAD+ individuals would have more small d<1.006 g/L lipoprotein particles. Several markers of PP lipid metabolism were measured over 10 h after a fat load. PP lipoprotein size and particle number were also determined. There was no significant difference in any measure of PP lipid metabolism between CAD+ and CAD-, except for apoB48, which was actually higher in CAD-. We followed 69 CAD- participants for a mean 8.7 years; 33 remained free of any cardiovascular event. There were no PP differences at baseline between these 33 who remained CAD- and either the 36 original CAD- who subsequently developed CAD or the original CAD+ group. PP measurements of TG-rich lipoproteins do not predict the presence of CAD in individuals with DM.
KW - Apolipoprotein B48
KW - Remnant lipoproteins
KW - Triglycerides
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U2 - 10.1194/jlr.M900092-JLR200
DO - 10.1194/jlr.M900092-JLR200
M3 - Article
C2 - 19429886
AN - SCOPUS:70350786366
VL - 50
SP - 1901
EP - 1909
JO - Journal of Lipid Research
JF - Journal of Lipid Research
SN - 0022-2275
IS - 9
ER -