Measures of postprandial lipoproteins are not associated with coronary artery disease in patients with type 2 diabetes mellitus

Gissette Reyes-Soffer, Steve Holleran, Wahida Karmally, Colleen I. Ngai, Niem Tzu Chen, Margarita Torres, Rajasekhar Ramakrishnan, William S. Blaner, Lars Berglund, Henry N. Ginsberg, Catherine Tuck

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Individuals with type 2 diabetes mellitus (DM) characteristically have elevated fasting and postprandial (PP) plasma triglycerides (TG). Previous case-control studies indicated that PPTG levels predict the presence of coronary artery disease (CAD) in people without DM; however, the data for patients with DM are conflicting. Therefore, we conducted a case-control study in DM individuals, 84 with (+) and 80 without (-) CAD. Our hypothesis was that DM individuals with or without CAD would have similar PPTG levels, but CAD+ individuals would have more small d<1.006 g/L lipoprotein particles. Several markers of PP lipid metabolism were measured over 10 h after a fat load. PP lipoprotein size and particle number were also determined. There was no significant difference in any measure of PP lipid metabolism between CAD+ and CAD-, except for apoB48, which was actually higher in CAD-. We followed 69 CAD- participants for a mean 8.7 years; 33 remained free of any cardiovascular event. There were no PP differences at baseline between these 33 who remained CAD- and either the 36 original CAD- who subsequently developed CAD or the original CAD+ group. PP measurements of TG-rich lipoproteins do not predict the presence of CAD in individuals with DM.

Original languageEnglish (US)
Pages (from-to)1901-1909
Number of pages9
JournalJournal of Lipid Research
Volume50
Issue number9
DOIs
StatePublished - 2009
Externally publishedYes

Keywords

  • Apolipoprotein B48
  • Remnant lipoproteins
  • Triglycerides

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Endocrinology

Fingerprint Dive into the research topics of 'Measures of postprandial lipoproteins are not associated with coronary artery disease in patients with type 2 diabetes mellitus'. Together they form a unique fingerprint.

  • Cite this

    Reyes-Soffer, G., Holleran, S., Karmally, W., Ngai, C. I., Chen, N. T., Torres, M., Ramakrishnan, R., Blaner, W. S., Berglund, L., Ginsberg, H. N., & Tuck, C. (2009). Measures of postprandial lipoproteins are not associated with coronary artery disease in patients with type 2 diabetes mellitus. Journal of Lipid Research, 50(9), 1901-1909. https://doi.org/10.1194/jlr.M900092-JLR200