Measurements of blood-brain barrier permeability in patients undergoing radiotherapy and chemotherapy for primary cerebral lymphoma

R. J. Ott, M. Brada, M. A. Flower, J. W. Babich, Simon R Cherry, B. J. Deehan

Research output: Contribution to journalArticle

93 Citations (Scopus)

Abstract

Positron emission tomography (PET) has been used to measure changes in regional blood-brain barrier (BBB) permeability in patients with primary cerebral lymphoma undergoing radiotherapy and chemotherapy. The method employed is to measure the rate of wash-out of a radioactive tracer (68Ga-EDTA) from blood into brain tissue using time-sequence PET imaging. Preliminary studies carried out on patients with more common primary cerebral tumours show that time-activity data are reproducible to ∼10%. Measurements made in 2 patients with primary cerebral lymphoma treated with initial chemotherapy showed significant changes in permeability in the region of the tumour. Within 5 weeks of the start of treatment, permeability values reached the levels of normal brain. No changes in BBB permeability in normal brain were seen immediately after radiotherapy.

Original languageEnglish (US)
Pages (from-to)1356-1361
Number of pages6
JournalEuropean Journal of Cancer and Clinical Oncology
Volume27
Issue number11
DOIs
StatePublished - 1991
Externally publishedYes

Fingerprint

Blood-Brain Barrier
Permeability
Lymphoma
Radiotherapy
Drug Therapy
Positron-Emission Tomography
Brain
Radioactive Tracers
Edetic Acid
Neoplasms
Therapeutics

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Measurements of blood-brain barrier permeability in patients undergoing radiotherapy and chemotherapy for primary cerebral lymphoma. / Ott, R. J.; Brada, M.; Flower, M. A.; Babich, J. W.; Cherry, Simon R; Deehan, B. J.

In: European Journal of Cancer and Clinical Oncology, Vol. 27, No. 11, 1991, p. 1356-1361.

Research output: Contribution to journalArticle

@article{12eccfa03c1e4981ac4b4dfbcb7b242d,
title = "Measurements of blood-brain barrier permeability in patients undergoing radiotherapy and chemotherapy for primary cerebral lymphoma",
abstract = "Positron emission tomography (PET) has been used to measure changes in regional blood-brain barrier (BBB) permeability in patients with primary cerebral lymphoma undergoing radiotherapy and chemotherapy. The method employed is to measure the rate of wash-out of a radioactive tracer (68Ga-EDTA) from blood into brain tissue using time-sequence PET imaging. Preliminary studies carried out on patients with more common primary cerebral tumours show that time-activity data are reproducible to ∼10{\%}. Measurements made in 2 patients with primary cerebral lymphoma treated with initial chemotherapy showed significant changes in permeability in the region of the tumour. Within 5 weeks of the start of treatment, permeability values reached the levels of normal brain. No changes in BBB permeability in normal brain were seen immediately after radiotherapy.",
author = "Ott, {R. J.} and M. Brada and Flower, {M. A.} and Babich, {J. W.} and Cherry, {Simon R} and Deehan, {B. J.}",
year = "1991",
doi = "10.1016/0277-5379(91)90009-3",
language = "English (US)",
volume = "27",
pages = "1356--1361",
journal = "European Journal of Cancer",
issn = "0959-8049",
publisher = "Elsevier Limited",
number = "11",

}

TY - JOUR

T1 - Measurements of blood-brain barrier permeability in patients undergoing radiotherapy and chemotherapy for primary cerebral lymphoma

AU - Ott, R. J.

AU - Brada, M.

AU - Flower, M. A.

AU - Babich, J. W.

AU - Cherry, Simon R

AU - Deehan, B. J.

PY - 1991

Y1 - 1991

N2 - Positron emission tomography (PET) has been used to measure changes in regional blood-brain barrier (BBB) permeability in patients with primary cerebral lymphoma undergoing radiotherapy and chemotherapy. The method employed is to measure the rate of wash-out of a radioactive tracer (68Ga-EDTA) from blood into brain tissue using time-sequence PET imaging. Preliminary studies carried out on patients with more common primary cerebral tumours show that time-activity data are reproducible to ∼10%. Measurements made in 2 patients with primary cerebral lymphoma treated with initial chemotherapy showed significant changes in permeability in the region of the tumour. Within 5 weeks of the start of treatment, permeability values reached the levels of normal brain. No changes in BBB permeability in normal brain were seen immediately after radiotherapy.

AB - Positron emission tomography (PET) has been used to measure changes in regional blood-brain barrier (BBB) permeability in patients with primary cerebral lymphoma undergoing radiotherapy and chemotherapy. The method employed is to measure the rate of wash-out of a radioactive tracer (68Ga-EDTA) from blood into brain tissue using time-sequence PET imaging. Preliminary studies carried out on patients with more common primary cerebral tumours show that time-activity data are reproducible to ∼10%. Measurements made in 2 patients with primary cerebral lymphoma treated with initial chemotherapy showed significant changes in permeability in the region of the tumour. Within 5 weeks of the start of treatment, permeability values reached the levels of normal brain. No changes in BBB permeability in normal brain were seen immediately after radiotherapy.

UR - http://www.scopus.com/inward/record.url?scp=0026000386&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026000386&partnerID=8YFLogxK

U2 - 10.1016/0277-5379(91)90009-3

DO - 10.1016/0277-5379(91)90009-3

M3 - Article

C2 - 1835848

AN - SCOPUS:0026000386

VL - 27

SP - 1356

EP - 1361

JO - European Journal of Cancer

JF - European Journal of Cancer

SN - 0959-8049

IS - 11

ER -