Systemic arterial and mixed venous plasma concentrations of 6-keto-PGF1α and TxB2 were measured by radioimmunoassay in 63 critically ill patients with major trauma (n = 20) or sepsis (n = 43). Patients undergoing elective catheterization procedures served as controls (n = 10). Arterial and mixed venous 6-keto-PGF1α and TxB2 levels were significantly elevated in patients with recent major trauma or active sepsis. The 6-keto-PGF1α levels were found to be significantly elevated in the non-survivors and in patients with hepatic failure. The presence of severe pulmonary failure was not associated with increased levels of either 6-keto-PGF1α or TxB2. Comparison of arterial and mixed plasma samples did not demonstrate increased pulmonary release of either compound. Increased eicosanoid production may account, in part, for the local vascular and humoral responses to tissue injury or infection.
|Original language||English (US)|
|Number of pages||7|
|Journal||Prostaglandins, Leukotrienes and Essential Fatty Acids|
|State||Published - 1988|
ASJC Scopus subject areas
- Clinical Biochemistry
- Endocrinology, Diabetes and Metabolism