Measles virus and Crohn's disease: A critical appraisal of the current literature

Andre J. Ouellette, Charles L Bevins

Research output: Contribution to journalArticle

38 Scopus citations

Abstract

The etiology of inflammatory bowel disease (IBD) is unknown. Recent reports in the literature have suggested that measles virus, both wild-type and vaccine-attenuated, might be a risk factor for Crohn's disease. We used the well-accepted Bradford-Hill criteria to evaluate the possible causal association between measles and IBD. Although the association may be biologically plausible, the literature lacks consistency, specificity, strength, and dose response. The current literature does not support an association between measles virus and IBD.

Original languageEnglish (US)
Pages (from-to)51-57
Number of pages7
JournalInflammatory Bowel Diseases
Volume7
Issue number1
StatePublished - 2001
Externally publishedYes

Keywords

  • Crohn's disease
  • Inflammatory bowel diseases
  • Measles
  • Measles vaccine
  • Risk factors
  • Ulcerative colitis

ASJC Scopus subject areas

  • Gastroenterology

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