Abstract
In this paper, we detail blood flow studies in a rat mammary adenocarcinoma model using contrast-enhanced ultrasound. Imaging was implemented on a Siemens Elegra, and utilized the subharmonic phase-inversion detection scheme introduced last year by Chomas, et al. Parameters used in these studies include a transmission frequency of 6 MHz, receive center frequency of 3 MHz, and transmitted pressures ranging from 800 kPa - 2.2 MPa. A base study was completed to observe normal tumor growth over a five-week period. Measures of mean replenishment time and integrated enhancement were evaluated and compared to the percentage of viable tumor observed with histology. Results obtained for replenishment measures in tumors were also compared with those obtained in the normal kidney cortex. Mean replenishment time intervals of 6-14 seconds were observed in the tumors. The histogram of replenishment times within a given tumor plane has a wide distribution. We hypothesize this may be due to variably and poorly perfused tissue, abnormal vascular architecture, and tortuosity. The zeroth and first moments of the histograms of integrated enhancement provided an additional method of analysis.
| Original language | English (US) |
|---|---|
| Title of host publication | Proceedings of the IEEE Ultrasonics Symposium |
| Editors | D.E. Yuhas, S.C. Schneider |
| Pages | 1977-1980 |
| Number of pages | 4 |
| Volume | 2 |
| State | Published - 2002 |
| Event | 2002 IEEE Ultrasonics Symposium - Munich, Germany Duration: Oct 8 2002 → Oct 11 2002 |
Other
| Other | 2002 IEEE Ultrasonics Symposium |
|---|---|
| Country | Germany |
| City | Munich |
| Period | 10/8/02 → 10/11/02 |
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ASJC Scopus subject areas
- Engineering(all)
Cite this
Mean flow rate and integrated perfusion estimates obtained with contrast-assisted ultrasound. / Sadlowski, Amy; Chomas, James; Pollard, Rachel E; Bloch, Susannah; Griffey, Stephen M; Wisner, Erik R; Ferrara, Katherine.
Proceedings of the IEEE Ultrasonics Symposium. ed. / D.E. Yuhas; S.C. Schneider. Vol. 2 2002. p. 1977-1980.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - Mean flow rate and integrated perfusion estimates obtained with contrast-assisted ultrasound
AU - Sadlowski, Amy
AU - Chomas, James
AU - Pollard, Rachel E
AU - Bloch, Susannah
AU - Griffey, Stephen M
AU - Wisner, Erik R
AU - Ferrara, Katherine
PY - 2002
Y1 - 2002
N2 - In this paper, we detail blood flow studies in a rat mammary adenocarcinoma model using contrast-enhanced ultrasound. Imaging was implemented on a Siemens Elegra, and utilized the subharmonic phase-inversion detection scheme introduced last year by Chomas, et al. Parameters used in these studies include a transmission frequency of 6 MHz, receive center frequency of 3 MHz, and transmitted pressures ranging from 800 kPa - 2.2 MPa. A base study was completed to observe normal tumor growth over a five-week period. Measures of mean replenishment time and integrated enhancement were evaluated and compared to the percentage of viable tumor observed with histology. Results obtained for replenishment measures in tumors were also compared with those obtained in the normal kidney cortex. Mean replenishment time intervals of 6-14 seconds were observed in the tumors. The histogram of replenishment times within a given tumor plane has a wide distribution. We hypothesize this may be due to variably and poorly perfused tissue, abnormal vascular architecture, and tortuosity. The zeroth and first moments of the histograms of integrated enhancement provided an additional method of analysis.
AB - In this paper, we detail blood flow studies in a rat mammary adenocarcinoma model using contrast-enhanced ultrasound. Imaging was implemented on a Siemens Elegra, and utilized the subharmonic phase-inversion detection scheme introduced last year by Chomas, et al. Parameters used in these studies include a transmission frequency of 6 MHz, receive center frequency of 3 MHz, and transmitted pressures ranging from 800 kPa - 2.2 MPa. A base study was completed to observe normal tumor growth over a five-week period. Measures of mean replenishment time and integrated enhancement were evaluated and compared to the percentage of viable tumor observed with histology. Results obtained for replenishment measures in tumors were also compared with those obtained in the normal kidney cortex. Mean replenishment time intervals of 6-14 seconds were observed in the tumors. The histogram of replenishment times within a given tumor plane has a wide distribution. We hypothesize this may be due to variably and poorly perfused tissue, abnormal vascular architecture, and tortuosity. The zeroth and first moments of the histograms of integrated enhancement provided an additional method of analysis.
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M3 - Conference contribution
VL - 2
SP - 1977
EP - 1980
BT - Proceedings of the IEEE Ultrasonics Symposium
A2 - Yuhas, D.E.
A2 - Schneider, S.C.
ER -