Abstract
Male Wistar Lewis rats were injected with maytansine at a total dose of 0.425 to 0.6 mg/kg over a 3-week period. Biopsies taken at 5 weeks showed that 23% of the bladders had hyperplasia or other abnormalities. Of the bladder biopsies done for the first time at 8 weeks, 80% demonstrated papillary hyperplasia. A small number of biopsies at 13 and 19 weeks still showed hyperplasia and minimal inflammatory reaction. These results were seen regardless of prior biopsy, the presence of bladder calculi, and/or the dose level used. It is not clear from the data whether the observed changes are reversible or precarcinogenic. However, these changes closely resembled the histologic features described in the evolution of bladder cancer in rats fed N-C4-(5-nitro-2-furyl)-2-thiazolyl formamide.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 183-184 |
| Number of pages | 2 |
| Journal | Cancer Treatment Reports |
| Volume | 67 |
| Issue number | 2 |
| State | Published - 1983 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Cancer Research
- Oncology
Cite this
Maytansine as a cause of acute proliferative disorder of bladder urethelium in the rat. / deVere White, Ralph W; O'Brien, M.; Krikorian, J.; Babayan, R.; Olsson, C. A.
In: Cancer Treatment Reports, Vol. 67, No. 2, 1983, p. 183-184.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Maytansine as a cause of acute proliferative disorder of bladder urethelium in the rat
AU - deVere White, Ralph W
AU - O'Brien, M.
AU - Krikorian, J.
AU - Babayan, R.
AU - Olsson, C. A.
PY - 1983
Y1 - 1983
N2 - Male Wistar Lewis rats were injected with maytansine at a total dose of 0.425 to 0.6 mg/kg over a 3-week period. Biopsies taken at 5 weeks showed that 23% of the bladders had hyperplasia or other abnormalities. Of the bladder biopsies done for the first time at 8 weeks, 80% demonstrated papillary hyperplasia. A small number of biopsies at 13 and 19 weeks still showed hyperplasia and minimal inflammatory reaction. These results were seen regardless of prior biopsy, the presence of bladder calculi, and/or the dose level used. It is not clear from the data whether the observed changes are reversible or precarcinogenic. However, these changes closely resembled the histologic features described in the evolution of bladder cancer in rats fed N-C4-(5-nitro-2-furyl)-2-thiazolyl formamide.
AB - Male Wistar Lewis rats were injected with maytansine at a total dose of 0.425 to 0.6 mg/kg over a 3-week period. Biopsies taken at 5 weeks showed that 23% of the bladders had hyperplasia or other abnormalities. Of the bladder biopsies done for the first time at 8 weeks, 80% demonstrated papillary hyperplasia. A small number of biopsies at 13 and 19 weeks still showed hyperplasia and minimal inflammatory reaction. These results were seen regardless of prior biopsy, the presence of bladder calculi, and/or the dose level used. It is not clear from the data whether the observed changes are reversible or precarcinogenic. However, these changes closely resembled the histologic features described in the evolution of bladder cancer in rats fed N-C4-(5-nitro-2-furyl)-2-thiazolyl formamide.
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UR - http://www.scopus.com/inward/citedby.url?scp=0020596787&partnerID=8YFLogxK
M3 - Article
C2 - 6825127
AN - SCOPUS:0020596787
VL - 67
SP - 183
EP - 184
JO - Journal of the National Cancer Institute
JF - Journal of the National Cancer Institute
SN - 0027-8874
IS - 2
ER -