May the force be with you: Transfer of healthy mitochondria from stem cells to stroke cells

Cesar V. Borlongan, Hung Nguyen, Trenton Lippert, Eleonora Russo, Julian Tuazon, Kaya Xu, Jea Young Lee, Paul R. Sanberg, Yuji Kaneko, Eleonora Napoli

Research output: Contribution to journalComment/debate

15 Scopus citations

Abstract

Stroke is a major cause of death and disability in the United States and around the world with limited therapeutic option. Here, we discuss the critical role of mitochondria in stem cell-mediated rescue of stroke brain by highlighting the concept that deleting the mitochondria from stem cells abolishes the cells’ regenerative potency. The application of innovative approaches entailing generation of mitochondria-voided stem cells as well as pharmacological inhibition of mitochondrial function may elucidate the mechanism underlying transfer of healthy mitochondria to ischemic cells, thereby providing key insights in the pathology and treatment of stroke and other brain disorders plagued with mitochondrial dysfunctions.

Original languageEnglish (US)
Pages (from-to)367-370
Number of pages4
JournalJournal of Cerebral Blood Flow and Metabolism
Volume39
Issue number2
DOIs
StatePublished - Feb 1 2019

Keywords

  • cellular bioenergetics
  • Cerebral ischemia
  • energy metabolism
  • inflammation
  • regenerative medicine
  • transplantation

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

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  • Cite this

    Borlongan, C. V., Nguyen, H., Lippert, T., Russo, E., Tuazon, J., Xu, K., Lee, J. Y., Sanberg, P. R., Kaneko, Y., & Napoli, E. (2019). May the force be with you: Transfer of healthy mitochondria from stem cells to stroke cells. Journal of Cerebral Blood Flow and Metabolism, 39(2), 367-370. https://doi.org/10.1177/0271678X18811277