Abstract
Standardized primed continuous glucose infusions were performed in 13 newborn lambs between 4 h and 2 weeks of age to assess the timing of development of glucose-induced early-phase insulin release. Lambs of less than 6 h of age behaved similar to those previously infused in utero, with no early response noted. In contrast, early-phase insulin release was present in lambs of 12 h of age and older. Although basal plasma glucose rose with increasing post-natal age, this rise was not sufficient to account for the appearance of early phase insulin release. Factors other than the basal glucose level or the birth process itself may be operative.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 225-231 |
| Number of pages | 7 |
| Journal | Biology of the Neonate |
| Volume | 39 |
| Issue number | 5-6 |
| State | Published - 1981 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Developmental Biology
- Pediatrics, Perinatology, and Child Health
Cite this
Maturation of early-phase insulin release in the neonatal lamb. / Philipps, Anthony F; Dubin, J. W.; Raye, J. R.
In: Biology of the Neonate, Vol. 39, No. 5-6, 1981, p. 225-231.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Maturation of early-phase insulin release in the neonatal lamb
AU - Philipps, Anthony F
AU - Dubin, J. W.
AU - Raye, J. R.
PY - 1981
Y1 - 1981
N2 - Standardized primed continuous glucose infusions were performed in 13 newborn lambs between 4 h and 2 weeks of age to assess the timing of development of glucose-induced early-phase insulin release. Lambs of less than 6 h of age behaved similar to those previously infused in utero, with no early response noted. In contrast, early-phase insulin release was present in lambs of 12 h of age and older. Although basal plasma glucose rose with increasing post-natal age, this rise was not sufficient to account for the appearance of early phase insulin release. Factors other than the basal glucose level or the birth process itself may be operative.
AB - Standardized primed continuous glucose infusions were performed in 13 newborn lambs between 4 h and 2 weeks of age to assess the timing of development of glucose-induced early-phase insulin release. Lambs of less than 6 h of age behaved similar to those previously infused in utero, with no early response noted. In contrast, early-phase insulin release was present in lambs of 12 h of age and older. Although basal plasma glucose rose with increasing post-natal age, this rise was not sufficient to account for the appearance of early phase insulin release. Factors other than the basal glucose level or the birth process itself may be operative.
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UR - http://www.scopus.com/inward/citedby.url?scp=0019521836&partnerID=8YFLogxK
M3 - Article
C2 - 7020780
AN - SCOPUS:0019521836
VL - 39
SP - 225
EP - 231
JO - Neonatology
JF - Neonatology
SN - 1661-7800
IS - 5-6
ER -