Matrix metalloproteinase control of capillary morphogenesis

Cyrus M. Ghajar, Steven George, Andrew J. Putnam

Research output: Contribution to journalReview article

82 Citations (Scopus)

Abstract

Matrix metalloproteinases (MMPs) play crucial roles in a variety of normal (e.g., blood vessel formation, bone development) and pathophysiological (e.g., wound healing, cancer) processes. This is not only due to their ability to degrade the surrounding extracellular matrix (ECM), but also because MMPs function to reveal cryptic matrix binding sites, release matrix-bound growth factors inherent to these processes, and activate a variety of cell surface molecules. The process of blood vessel formation, in particular, is regulated by what is widely classified as the angiogenic switch: a mixture of both pro- and antiangiogenic factors that function to counteract each other unless the stimuli from one side exceeds the other to disrupt the quiescent state. Although it was initially thought that MMPs were strictly proangiogenic, new functions for this proteolytic family, such as mediating vascular regression and generating matrix fragments with antiangiogenic capacities, have been discovered in the last decade. These findings cast MMPs as multifaceted pro- and antiangiogenic effectors. The purpose of this review is to introduce the reader to the general structure and characterization of the MMP family and to discuss the temporal and spatial regulation of their gene expression and enzymatic activity in the following crucial steps associated with angiogenesis: degradation of the vascular basement membrane, proliferation and invasion of endothelial cells within the subjacent ECM, organization into immature tubules, maturation of these nascent vessels, and the pruning and regression of the vascular network.

Original languageEnglish (US)
Pages (from-to)251-278
Number of pages28
JournalCritical Reviews in Eukaryotic Gene Expression
Volume18
Issue number3
DOIs
StatePublished - Jan 1 2008

Fingerprint

Matrix Metalloproteinases
Morphogenesis
Blood Vessels
Extracellular Matrix
Bone Development
Gene Expression Regulation
Basement Membrane
Wound Healing
Intercellular Signaling Peptides and Proteins
Endothelial Cells
Binding Sites
Neoplasms

Keywords

  • Angiogenesis
  • Capillary morphogenesis
  • Matrix
  • Vasculogenisis

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

Cite this

Matrix metalloproteinase control of capillary morphogenesis. / Ghajar, Cyrus M.; George, Steven; Putnam, Andrew J.

In: Critical Reviews in Eukaryotic Gene Expression, Vol. 18, No. 3, 01.01.2008, p. 251-278.

Research output: Contribution to journalReview article

Ghajar, Cyrus M. ; George, Steven ; Putnam, Andrew J. / Matrix metalloproteinase control of capillary morphogenesis. In: Critical Reviews in Eukaryotic Gene Expression. 2008 ; Vol. 18, No. 3. pp. 251-278.
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