Matrix concentration of insulin-like growth factor I (IGF-I) is negatively associated with biomechanical properties of human tibial cancellous bone within individual subjects

X. N. Dong, Y. N. Yeni, B. Zhang, C. M. Les, G. J. Gibson, David P Fyhrie

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Insulin-like growth factor-I (IGF-I), abundant in bone matrix, is believed to play an important role during bone development and remodeling. To our knowledge, however, few studies have addressed the relationship between the concentration of IGF-I in bone matrix and the biomechanical properties of bone tissue. In this study, forty-five cylindrical specimens of cancellous bone were harvested from six human tibiae and scanned using microcomputed tomography (μCT). The bone volume fraction (BV/TV) was calculated from three-dimensional (3D) μCT images. Mechanical tests were then performed on a servohydraulic testing system to determine the strength and stiffness of cancellous bone. Following mechanical testing, the concentration of IGF-I in bone matrix was measured by using an enzyme-linked immunoabsorbent assay (ELISA). Within each subject, the concentration of IGF-I in bone matrix had significant (P < 0.01) negative correlations with the bone volume fraction, strength, and stiffness of cancellous bone. In particular, the anterior quadrant of the proximal tibia was significantly (P < 0.02) greater in IGF-I matrix concentration and marginally significantly lower in strength (P = 0.053) and stiffness (P = 0.059) than the posterior quadrant. The negative correlations between the cancellous bone matrix concentration of IGF-I and cancellous bone biomechanical properties within subjects found in this study may help us understand the variation of the biomechanical properties of cancellous bone in proximal human tibiae.

Original languageEnglish (US)
Pages (from-to)37-44
Number of pages8
JournalCalcified Tissue International
Volume77
Issue number1
DOIs
StatePublished - Jul 2005
Externally publishedYes

Keywords

  • Bone volume fraction
  • Cancellous bone
  • Insulin-like growth factor-I
  • Strength
  • Tibia

ASJC Scopus subject areas

  • Endocrinology

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