Mathematics of cell motility: Have we got its number?

Alex Mogilner

Research output: Contribution to journalArticle

168 Scopus citations

Abstract

Mathematical and computational modeling is rapidly becoming an essential research technique complementing traditional experimental biological methods. However, lack of standardmodelingmethods, difficulties of translating biological phenomena into mathematical language, and differences in biological and mathematical mentalities continue to hinder the scientific progress. Here we focus on one area- cell motility-characterized by an unusually high modeling activity, largely due to a vast amount of quantitative, biophysical data, 'modular' character of motility, and pioneering vision of the area's experimental leaders. In this review, after brief introduction to biology of cell movements, we discuss quantitative models of actin dynamics, protrusion, adhesion, contraction, and cell shape and movement that made an impact on the process of biological discovery.We also comment on modeling approaches and open questions.

Original languageEnglish (US)
Pages (from-to)105-134
Number of pages30
JournalJournal of Mathematical Biology
Volume58
Issue number1-2
DOIs
StatePublished - Jan 2009

    Fingerprint

Keywords

  • Actin
  • Adhesion
  • Cell mechanics
  • Cell motility
  • Contraction
  • Protrusion

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Applied Mathematics
  • Modeling and Simulation

Cite this