Mathematical and physical modeling of actin dynamics in motile cells

Anders E. Carlsson, Alex Mogilner

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Citations (Scopus)

Abstract

Mathematical modeling has been very instrumental in aiding traditional experimental methods in uncovering the mysteries of actin dynamics. Here we review recent quantitative models of actin dynamics focusing on ATPATP hydrolysishydrolysis effects, forceforce generation by single actin filaments and networks, self-organization and dynamics of actin networks, dynamics of lamellipodialamellipodia, filopodia and lamella, and integrative mechanochemistry of whole motile cells. We discuss both modeling methods and specific insights from modeling that helped answering biological questions.

Original languageEnglish (US)
Title of host publicationActin-based Motility: Cellular, Molecular and Physical Aspects
PublisherSpringer Netherlands
Pages381-412
Number of pages32
ISBN (Print)9789048193011, 9789048193004
DOIs
StatePublished - 2010

Fingerprint

Actins
Cohort Effect
Pseudopodia
Actin Cytoskeleton

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Carlsson, A. E., & Mogilner, A. (2010). Mathematical and physical modeling of actin dynamics in motile cells. In Actin-based Motility: Cellular, Molecular and Physical Aspects (pp. 381-412). Springer Netherlands. https://doi.org/10.1007/978-90-481-9301-1_16

Mathematical and physical modeling of actin dynamics in motile cells. / Carlsson, Anders E.; Mogilner, Alex.

Actin-based Motility: Cellular, Molecular and Physical Aspects. Springer Netherlands, 2010. p. 381-412.

Research output: Chapter in Book/Report/Conference proceedingChapter

Carlsson, AE & Mogilner, A 2010, Mathematical and physical modeling of actin dynamics in motile cells. in Actin-based Motility: Cellular, Molecular and Physical Aspects. Springer Netherlands, pp. 381-412. https://doi.org/10.1007/978-90-481-9301-1_16
Carlsson AE, Mogilner A. Mathematical and physical modeling of actin dynamics in motile cells. In Actin-based Motility: Cellular, Molecular and Physical Aspects. Springer Netherlands. 2010. p. 381-412 https://doi.org/10.1007/978-90-481-9301-1_16
Carlsson, Anders E. ; Mogilner, Alex. / Mathematical and physical modeling of actin dynamics in motile cells. Actin-based Motility: Cellular, Molecular and Physical Aspects. Springer Netherlands, 2010. pp. 381-412
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