Maternal vitamin use and reduced risk of neuroblastoma

Andrew F. Olshan, Joanna C. Smith, Melissa L. Bondy, Joseph P. Neglia, Bradley H Pollock

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

Background. Previous studies have suggested that maternal vitamin use during pregnancy may reduce the incidence of childhood brain tumors. Using data from a large North American study, we conducted an analysis to investigate maternal vitamin use and neuroblastoma in offspring. Methods. Cases were children diagnosed with neuroblastoma over the period 1 May 1992 to 30 April 1994 at Children's Cancer Group and Pediatric Oncology Group institutions throughout the United States and Canada. One matched control was selected for each case using random-digit dialing. We obtained vitamin use information during specific periods before and during pregnancy from 538 case and 504 control mothers through telephone interviews. Results. Daily vitamin and mineral use in the month before pregnancy and in each trimester was associated with a 30-40% reduction in risk of neuroblastoma. For example, daily use in the second trimester had an odds ratio of 0.6 (95% confidence interval = 0.4-0.9). We were unable to isolate the effects of specific vitamins or minerals. Neither age at diagnosis nor MYCN oncogene amplification status materially altered the results. Conclusions. The results of this study suggest that vitamin use during pregnancy might reduce incidence of neuroblastoma, consistent with findings for other childhood cancers.

Original languageEnglish (US)
Pages (from-to)575-580
Number of pages6
JournalEpidemiology
Volume13
Issue number5
StatePublished - Sep 2002
Externally publishedYes

Fingerprint

Neuroblastoma
Vitamins
Mothers
Pregnancy
Minerals
Incidence
Second Pregnancy Trimester
Risk Reduction Behavior
Oncogenes
Brain Neoplasms
Canada
Neoplasms
Odds Ratio
Confidence Intervals
Interviews
Pediatrics

Keywords

  • Childhood
  • Neuroblastoma
  • Pregnancy
  • Vitamins

ASJC Scopus subject areas

  • Epidemiology

Cite this

Olshan, A. F., Smith, J. C., Bondy, M. L., Neglia, J. P., & Pollock, B. H. (2002). Maternal vitamin use and reduced risk of neuroblastoma. Epidemiology, 13(5), 575-580.

Maternal vitamin use and reduced risk of neuroblastoma. / Olshan, Andrew F.; Smith, Joanna C.; Bondy, Melissa L.; Neglia, Joseph P.; Pollock, Bradley H.

In: Epidemiology, Vol. 13, No. 5, 09.2002, p. 575-580.

Research output: Contribution to journalArticle

Olshan, AF, Smith, JC, Bondy, ML, Neglia, JP & Pollock, BH 2002, 'Maternal vitamin use and reduced risk of neuroblastoma', Epidemiology, vol. 13, no. 5, pp. 575-580.
Olshan AF, Smith JC, Bondy ML, Neglia JP, Pollock BH. Maternal vitamin use and reduced risk of neuroblastoma. Epidemiology. 2002 Sep;13(5):575-580.
Olshan, Andrew F. ; Smith, Joanna C. ; Bondy, Melissa L. ; Neglia, Joseph P. ; Pollock, Bradley H. / Maternal vitamin use and reduced risk of neuroblastoma. In: Epidemiology. 2002 ; Vol. 13, No. 5. pp. 575-580.
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