Maternal Mid-Pregnancy Autoantibodies to Fetal Brain Protein: The Early Markers for Autism Study

Lisa A. Croen, Daniel Braunschweig, Lori Haapanen, Cathleen K. Yoshida, Bruce Fireman, Judith K. Grether, Martin Kharrazi, Robin L Hansen, Paul Ashwood, Judith A Van de Water

Research output: Contribution to journalArticle

121 Scopus citations

Abstract

Background: Immune dysfunction has been associated with autism, yet whether maternal immune status during pregnancy plays a causal role remains to be clarified. Methods: We conducted a population-based case-control study nested within the cohort of infants born July 2000-September 2001 to women who participated in the prenatal screening program in Orange County, California. Cases (AU; n = 84) were children receiving services for autism at the Regional Center of Orange County. Two control groups were included: children with mental retardation or developmental delay (MR; n = 49) receiving services at the same regional center; and children not receiving services for developmental disabilities, randomly sampled from the California birth certificate files (GP; n = 160). Maternal autoantibody reactivity to fetal brain protein was measured by Western blot in archived mid-pregnancy blood specimens drawn during routine prenatal screening. Presence of specific bands and band patterns were compared between the three study groups. Results: The pattern of maternal mid-gestation antibody reactivity to human fetal brain protein varied by study group and by autism onset type, although most differences did not reach statistical significance. Reactivity to a band at 39 kDa was more common among mothers of children with autism (7%) compared with mothers of MR (0%; p = .09) and GP control subjects (2%; p = .07), and simultaneous reactivity to bands at 39 kDa and 73 kDa was found only in mothers of children with early onset autism (n = 3). Conclusions: Our findings indicate that further studies of prenatal immune markers might be a productive area for etiologic and biologic marker discovery for autism.

Original languageEnglish (US)
Pages (from-to)583-588
Number of pages6
JournalBiological Psychiatry
Volume64
Issue number7
DOIs
StatePublished - Oct 1 2008

Keywords

  • ASD
  • autism
  • autoimmune
  • biologic marker
  • neonatal
  • prenatal

ASJC Scopus subject areas

  • Biological Psychiatry

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