Maternal metabolic conditions and risk for autism and other neurodevelopmental disorders

Paula Krakowiak, Cheryl K. Walker, Andrew A. Bremer, Alice S. Baker, Sally J Ozonoff, Robin L Hansen, Irva Hertz-Picciotto

Research output: Contribution to journalArticle

305 Citations (Scopus)

Abstract

OBJECTIVE: We examined whether metabolic conditions (MCs) during pregnancy (diabetes, hypertension, and obesity) are associated with autism spectrum disorder (ASD), developmental delays (DD), or impairments in specific domains of development in the offspring. METHODS: Children aged 2 to 5 years (517 ASD, 172 DD, and 315 controls) were enrolled in the CHARGE (Childhood Autism Risks from Genetics and the Environment) study, a population-based, case-control investigation between January 2003 and June 2010. Eligible children were born in California, had parents who spoke English or Spanish, and were living with a biological parent in selected regions of California. Children's diagnoses were confirmed by using standardized assessments. Information regarding maternal conditions was ascertained from medical records or structured interview with the mother. RESULTS: All MCs were more prevalent among case mothers compared with controls. Collectively, these conditions were associated with a higher likelihood of ASD and DD relative to controls (odds ratio: 1.61 [95% confidence interval: 1.10-2.37; odds ratio: 2.35 [95% confidence interval: 1.43-3.88], respectively). Among ASD cases, children of women with diabetes had Mullen Scales of Early Learning (MSEL) expressive language scores 0.4 SD lower than children of mothers without MCs (P < .01). Among children without ASD, those exposed to any MC scored lower on all MSEL and Vineland Adaptive Behavior Scales (VABS) subscales and composites by at least 0.4 SD (P < .01 for each subscale/composite). CONCLUSIONS: Maternal MCs may be broadly associated with neuro-developmental problems in children. With obesity rising steadily, these results appear to raise serious public health concerns.

Original languageEnglish (US)
JournalPediatrics
Volume129
Issue number5
DOIs
StatePublished - May 2012

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Autistic Disorder
Mothers
Obesity
Odds Ratio
Learning
Confidence Intervals
Psychological Adaptation
Neurodevelopmental Disorders
Autism
Medical Records
Language
Public Health
Parents
Autism Spectrum Disorder
Autism Spectrum Disorders
Interviews
Hypertension
Pregnancy
Population

Keywords

  • Autism
  • Developmental delay
  • Diabetes
  • Epidemiology
  • Hypertension
  • Obesity

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Arts and Humanities (miscellaneous)

Cite this

Maternal metabolic conditions and risk for autism and other neurodevelopmental disorders. / Krakowiak, Paula; Walker, Cheryl K.; Bremer, Andrew A.; Baker, Alice S.; Ozonoff, Sally J; Hansen, Robin L; Hertz-Picciotto, Irva.

In: Pediatrics, Vol. 129, No. 5, 05.2012.

Research output: Contribution to journalArticle

Krakowiak, Paula ; Walker, Cheryl K. ; Bremer, Andrew A. ; Baker, Alice S. ; Ozonoff, Sally J ; Hansen, Robin L ; Hertz-Picciotto, Irva. / Maternal metabolic conditions and risk for autism and other neurodevelopmental disorders. In: Pediatrics. 2012 ; Vol. 129, No. 5.
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abstract = "OBJECTIVE: We examined whether metabolic conditions (MCs) during pregnancy (diabetes, hypertension, and obesity) are associated with autism spectrum disorder (ASD), developmental delays (DD), or impairments in specific domains of development in the offspring. METHODS: Children aged 2 to 5 years (517 ASD, 172 DD, and 315 controls) were enrolled in the CHARGE (Childhood Autism Risks from Genetics and the Environment) study, a population-based, case-control investigation between January 2003 and June 2010. Eligible children were born in California, had parents who spoke English or Spanish, and were living with a biological parent in selected regions of California. Children's diagnoses were confirmed by using standardized assessments. Information regarding maternal conditions was ascertained from medical records or structured interview with the mother. RESULTS: All MCs were more prevalent among case mothers compared with controls. Collectively, these conditions were associated with a higher likelihood of ASD and DD relative to controls (odds ratio: 1.61 [95{\%} confidence interval: 1.10-2.37; odds ratio: 2.35 [95{\%} confidence interval: 1.43-3.88], respectively). Among ASD cases, children of women with diabetes had Mullen Scales of Early Learning (MSEL) expressive language scores 0.4 SD lower than children of mothers without MCs (P < .01). Among children without ASD, those exposed to any MC scored lower on all MSEL and Vineland Adaptive Behavior Scales (VABS) subscales and composites by at least 0.4 SD (P < .01 for each subscale/composite). CONCLUSIONS: Maternal MCs may be broadly associated with neuro-developmental problems in children. With obesity rising steadily, these results appear to raise serious public health concerns.",
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