Maternal lifestyle and environmental risk factors for autism spectrum disorders

Research output: Contribution to journalArticle

139 Citations (Scopus)

Abstract

Background: Over the past 10 years, research into environmental risk factors for autism has grown dramatically, bringing evidence that an array of non-genetic factors acting during the prenatal period may influence neurodevelopment.Methods: This paper reviews the evidence on modifiable preconception and/or prenatal factors that have been associated, in some studies, with autism spectrum disorder (ASD), including nutrition, substance use and exposure to environmental agents. This review is restricted to human studies with at least 50 cases of ASD, having a valid comparison group, conducted within the past decade and focusing on maternal lifestyle or environmental chemicals.Results: Higher maternal intake of certain nutrients and supplements has been associated with reduction in ASD risk, with the strongest evidence for periconceptional folic acid supplements. Although many investigations have suggested no impact of maternal smoking and alcohol use on ASD, more rigorous exposure assessment is needed. A number of studies have demonstrated significant increases in ASD risk with estimated exposure to air pollution during the prenatal period, particularly for heavy metals and particulate matter. Little research has assessed other persistent and non-persistent organic pollutants in association with ASD specifically.Conclusions: More work is needed to examine fats, vitamins and other maternal nutrients, as well as endocrine-disrupting chemicals and pesticides, in association with ASD, given sound biological plausibility and evidence regarding other neurodevelopmental deficits. The field can be advanced by large-scale epidemiological studies, attention to critical aetiological windows and how these vary by exposure, and use of biomarkers and other means to understand underlying mechanisms.

Original languageEnglish (US)
Article numberdyt282
Pages (from-to)443-464
Number of pages22
JournalInternational Journal of Epidemiology
Volume43
Issue number2
DOIs
StatePublished - 2014

Fingerprint

Life Style
Mothers
Endocrine Disruptors
Food
Particulate Matter
Air Pollution
Environmental Exposure
Autistic Disorder
Heavy Metals
Autism Spectrum Disorder
Folic Acid
Research
Pesticides
Vitamins
Epidemiologic Studies
Biomarkers
Smoking
Fats
Alcohols

Keywords

  • Air pollution
  • Autism
  • Environmental chemicals
  • Environmental risk factors
  • Maternal alcohol use
  • Maternal nutrition
  • Maternal smoking

ASJC Scopus subject areas

  • Epidemiology
  • Medicine(all)

Cite this

Maternal lifestyle and environmental risk factors for autism spectrum disorders. / Lyall, Kristen; Schmidt, Rebecca Jean; Hertz-Picciotto, Irva.

In: International Journal of Epidemiology, Vol. 43, No. 2, dyt282, 2014, p. 443-464.

Research output: Contribution to journalArticle

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