Maternal inheritance of mitochondrial DNA polymorphisms in cultured human fibroblasts

James Case, Douglas C. Wallace

Research output: Contribution to journalArticle

66 Scopus citations

Abstract

We have isolated the total cellular DNA from the cultured diploid fibroblasts of a six-member, three-generation human family. Using a specific radioactive probe for mitochondrial (mt) sequences we have identified new polymorphic variants in this family for the Hhal restriction endonuclease cleavage pattern of the mtDNA. The inheritance of these cleavage patterns verifies the maternal inheritance of mtDNA through all three generations.

Original languageEnglish (US)
Pages (from-to)103-108
Number of pages6
JournalSomatic Cell Genetics
Volume7
Issue number1
DOIs
StatePublished - Jan 1 1981

ASJC Scopus subject areas

  • Medicine(all)
  • Genetics

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