Maternal immune-mediated conditions, autism spectrum disorders, and developmental delay

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

The maternal immune system may play a role in offspring neurodevelopment. We examined whether maternal autoimmune disease, asthma, and allergy were associated with child autism spectrum disorder (ASD) and developmental delay without autism (DD) using 560 ASD cases, 391 typically developing controls, and 168 DD cases from the CHildhood Autism Risk from Genetics and the Environment (CHARGE) study. Results from conditional logistic regression demonstrated few significant associations overall. Maternal autoimmune disease was significantly associated with a modest increase in odds of developmental disorders (combined ASD + DD; OR = 1.46, 95 % CI 1.01, 2.09) but not of ASD alone. Associations with certain allergens and onset periods were also suggested. These findings suggest maternal autoimmune disease may modestly influence childhood developmental disorders (ASD + DD).

Original languageEnglish (US)
Pages (from-to)1546-1555
Number of pages10
JournalJournal of Autism and Developmental Disorders
Volume44
Issue number7
DOIs
StatePublished - 2014

Keywords

  • Allergy
  • Asthma
  • Autism
  • Autoimmune disease
  • Developmental delay
  • Maternal risk factors

ASJC Scopus subject areas

  • Developmental and Educational Psychology
  • Medicine(all)

Fingerprint Dive into the research topics of 'Maternal immune-mediated conditions, autism spectrum disorders, and developmental delay'. Together they form a unique fingerprint.

  • Cite this