Maternal immune activation: Implications for neuropsychiatric disorders

Myka L. Estes, A Kimberley Usrey

Research output: Contribution to journalReview article

274 Scopus citations

Abstract

Epidemiological evidence implicates maternal infection as a risk factor for autism spectrum disorder and schizophrenia. Animal models corroborate this link and demonstrate that maternal immune activation (MIA) alone is sufficient to impart lifelong neuropathology and altered behaviors in offspring.ThisReviewdescribes commonprinciples revealed by these models, highlighting recent findings that strengthen their relevance for schizophrenia and autism and are starting to reveal themolecularmechanisms underlying the effects of MIAon offspring.The role ofMIAas a primer for a much wider range of psychiatric and neurologic disorders is also discussed. Finally, the need for more research in this nascent field and the implications for identifying and developing new treatments for individuals at heightened risk for neuroimmune disorders are considered.

Original languageEnglish (US)
Pages (from-to)772-777
Number of pages6
JournalScience
Volume353
Issue number6301
DOIs
StatePublished - Aug 19 2016

ASJC Scopus subject areas

  • Medicine(all)
  • General

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