Maternal-fetal glucose metabolism and fetal growth retardation: Is there an association?

Jeanna M. Piper, Nancy T Field, Kenneth Higby, Byron D. Elliott, Oded Langer

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

OBJECTIVE: To test the hypothesis that in normotensive pregnancies decreased maternal glucose response leads to relative fetal hypoglycemia and hypoinsulinemia, which result in delayed fetal growth. STUDY DESIGN: We enrolled patients with and without risk factors for growth retardation. Each under went an oral glucose tolerance test with both glucose and insulin evaluation. Cord blood was obtained for glucose and insulin evaluation. RESULTS: The normotensive pregnancies at risk had lower maternal glucose levels (index, 91 vs. 116 mg/dL; P < .05), a trend to ward lower maternal insulin levels (index, 398 vs. 483 μIU/mL; P = NS) and normal maternal insulin/glucose ratios. We found no differences, however, in the fetal metabolic parameters (glucose 83 vs. 78 mg/dL, insulin 17 vs. 24 μIU/mL; P = NS). CONCLUSION: Maternal glucose metabolism is altered in nonhypertensive pregnancies, with a risk of delayed fetal growth; however, the fetal glucose response may remain normal in the face of fetal growth retardation.

Original languageEnglish (US)
Pages (from-to)761-766
Number of pages6
JournalJournal of Reproductive Medicine for the Obstetrician and Gynecologist
Volume41
Issue number10
StatePublished - Oct 1996
Externally publishedYes

Fingerprint

Fetal Growth Retardation
Mothers
Glucose
Insulin
Fetal Development
Pregnancy
Glucose Tolerance Test
Fetal Blood
Hypoglycemia
Growth

Keywords

  • fetal growth retardation
  • glucose

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Reproductive Medicine

Cite this

Maternal-fetal glucose metabolism and fetal growth retardation : Is there an association? / Piper, Jeanna M.; Field, Nancy T; Higby, Kenneth; Elliott, Byron D.; Langer, Oded.

In: Journal of Reproductive Medicine for the Obstetrician and Gynecologist, Vol. 41, No. 10, 10.1996, p. 761-766.

Research output: Contribution to journalArticle

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AB - OBJECTIVE: To test the hypothesis that in normotensive pregnancies decreased maternal glucose response leads to relative fetal hypoglycemia and hypoinsulinemia, which result in delayed fetal growth. STUDY DESIGN: We enrolled patients with and without risk factors for growth retardation. Each under went an oral glucose tolerance test with both glucose and insulin evaluation. Cord blood was obtained for glucose and insulin evaluation. RESULTS: The normotensive pregnancies at risk had lower maternal glucose levels (index, 91 vs. 116 mg/dL; P < .05), a trend to ward lower maternal insulin levels (index, 398 vs. 483 μIU/mL; P = NS) and normal maternal insulin/glucose ratios. We found no differences, however, in the fetal metabolic parameters (glucose 83 vs. 78 mg/dL, insulin 17 vs. 24 μIU/mL; P = NS). CONCLUSION: Maternal glucose metabolism is altered in nonhypertensive pregnancies, with a risk of delayed fetal growth; however, the fetal glucose response may remain normal in the face of fetal growth retardation.

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