Maternal factors affecting teratogenic response

A need for assessment

Carl L Keen

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

A review of current literature suggests that maternal nutritional status can be an important modulator of the developmental toxicity of a number of agents in the environment. While the provision of multivitamin/multimineral supplements during the periconceptional period is often associated with improved pregnancy outcome, it has been difficult to identify specific nutrient deficiencies as causative factors of abnormal development in humans. One explanation for this is that nutrient deficiencies can arise through a number of means in addition to a simple dietary deficit of the nutrient. The hypothesis is proposed that one mechanism contributing to the embryotoxicity of a diverse group of insults is an alteration in the metabolism of select nutrients. Evidence is presented that zinc is one nutrient whose metabolism can be markedly influenced by a variety of insults. One consequence of this alteration can be a reduction in embryonic zinc uptake, the development of embryonic zinc deficiency and abnormal development.

Original languageEnglish (US)
Pages (from-to)15-21
Number of pages7
JournalTeratology
Volume46
Issue number1
DOIs
StatePublished - 1992

Fingerprint

Needs Assessment
Nutrients
Mothers
Food
Zinc
Metabolism
Human Development
Pregnancy Outcome
Nutritional Status
Modulators
Embryonic Development
Toxicity

ASJC Scopus subject areas

  • Developmental Biology
  • Embryology
  • Toxicology
  • Health, Toxicology and Mutagenesis

Cite this

Maternal factors affecting teratogenic response : A need for assessment. / Keen, Carl L.

In: Teratology, Vol. 46, No. 1, 1992, p. 15-21.

Research output: Contribution to journalArticle

Keen, Carl L. / Maternal factors affecting teratogenic response : A need for assessment. In: Teratology. 1992 ; Vol. 46, No. 1. pp. 15-21.
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