Maternal diet during pregnancy and its association with medulloblastoma in children: A children's oncology group study (United States)

Greta R. Bunin, Lawrence H. Kushi, Paul R. Gallagher, Lucy B. Rorke-Adams, Mary L. McBride, Avital Cnaan

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Fruit, vegetables, vitamin C, and folate during pregnancy have been suggested as protective factors for medulloblastoma/primitive neuroectodermal tumor (PNET), a common brain tumor in children. The authors sought to replicate these findings and investigate other aspects of diet. Mothers of 315 cases under age six at diagnosis and 315 controls were interviewed about their pregnancy diet. The authors observed modest, inverse associations for fruits/juices (odds ratio (OR) for highest compared to lowest category = 0.6, 95% confidence interval (CI): 0.3, 1.1) and vitamin C (OR = 0.6, 95% CI: 0.4, 1.1). In contrast to the previous study, folate and vegetables showed no association. As hypothesized, cured meats were not associated with medulloblastoma/PNET, in contrast to other childhood brain tumors. An inverse association with nonfresh peaches and similar fruits (OR = 0.5, 95% CI: 0.3, 0.8) and a positive association with nonchocolate candy (OR = 1.7, 95% CI: 1.0, 3.0) replicated previous findings. French fries (OR = 2.4, 95% CI: 1.2, 4.9) and chili peppers (OR = 1.8, 95% CI: 1.0, 3.0) were associated with medulloblastoma/PNET. The results suggest that some aspects of diet are worthy of further research.

Original languageEnglish (US)
Pages (from-to)877-891
Number of pages15
JournalCancer Causes and Control
Volume16
Issue number7
DOIs
StatePublished - Sep 2005
Externally publishedYes

Fingerprint

Medulloblastoma
Odds Ratio
Mothers
Confidence Intervals
Diet
Primitive Neuroectodermal Tumors
Pregnancy
Folic Acid
Brain Neoplasms
Vegetables
Ascorbic Acid
Fruit
Candy
Capsicum
Meat
Research

Keywords

  • Brain neoplasms
  • Case-control studies
  • Child
  • diet
  • Medulloblastoma
  • Preschool

ASJC Scopus subject areas

  • Oncology
  • Epidemiology
  • Cancer Research

Cite this

Maternal diet during pregnancy and its association with medulloblastoma in children : A children's oncology group study (United States). / Bunin, Greta R.; Kushi, Lawrence H.; Gallagher, Paul R.; Rorke-Adams, Lucy B.; McBride, Mary L.; Cnaan, Avital.

In: Cancer Causes and Control, Vol. 16, No. 7, 09.2005, p. 877-891.

Research output: Contribution to journalArticle

Bunin, Greta R. ; Kushi, Lawrence H. ; Gallagher, Paul R. ; Rorke-Adams, Lucy B. ; McBride, Mary L. ; Cnaan, Avital. / Maternal diet during pregnancy and its association with medulloblastoma in children : A children's oncology group study (United States). In: Cancer Causes and Control. 2005 ; Vol. 16, No. 7. pp. 877-891.
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