Maternal caffeine consumption and risk of congenital limb deficiencies

Lei Chen, Erin M. Bell, Marilyn L. Browne, Charlotte M. Druschel, Paul A. Romitti, Rebecca Jean Schmidt, Trudy L. Burns, Roxana Moslehi, Richard S. Olney

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

BACKGROUND: Animal studies have shown that high doses of caffeine might cause congenital limb deficiencies (LDs); however, no epidemiologic studies have explored this relation. METHODS: This case-control study assessed associations between maternal dietary caffeine and congenital LDs using data from the National Birth Defects Prevention Study (NBDPS), with 844 LD cases and 8069 controls from 1997 to 2007. Caffeine intakes from beverages (coffee, tea, and soda) and chocolate combined and by beverage type were examined. Adjusted odds ratios (aORs) and 95% confidence intervals (CIs) were estimated for subtypes of isolated LDs (no additional major anomalies) and LDs with other major anomalies separately, comparing the odds of 10 to <100, 100 to <200, 200 to <300, and 300+ mg/day total caffeine intake to 0 to <10 mg/day. RESULTS: All total dietary caffeine intake categories of 10 mg/day and above were marginally associated with odds of all isolated LDs combined (aOR, 1.4-1.7), isolated longitudinal LDs (aOR, 1.2-1.6), and isolated transverse LDs (aOR, 1.3-1.8) compared to the lowest intake category. A dose-response pattern for total dietary caffeine intake was not observed. CONCLUSIONS: A weak increased risk of congenital LDs associated with maternal dietary caffeine consumption was observed in this study; however, risk did not vary by amount of caffeine consumed.

Original languageEnglish (US)
Pages (from-to)1033-1043
Number of pages11
JournalBirth Defects Research Part A - Clinical and Molecular Teratology
Volume94
Issue number12
DOIs
StatePublished - Dec 2012

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Caffeine
Extremities
Mothers
Beverages
Coffee
Tea
Case-Control Studies
Epidemiologic Studies
Odds Ratio
Confidence Intervals

Keywords

  • Caffeine
  • Coffee
  • Congenital limb deficiencies
  • Soda
  • Tea

ASJC Scopus subject areas

  • Developmental Biology
  • Pediatrics, Perinatology, and Child Health
  • Embryology

Cite this

Maternal caffeine consumption and risk of congenital limb deficiencies. / Chen, Lei; Bell, Erin M.; Browne, Marilyn L.; Druschel, Charlotte M.; Romitti, Paul A.; Schmidt, Rebecca Jean; Burns, Trudy L.; Moslehi, Roxana; Olney, Richard S.

In: Birth Defects Research Part A - Clinical and Molecular Teratology, Vol. 94, No. 12, 12.2012, p. 1033-1043.

Research output: Contribution to journalArticle

Chen, L, Bell, EM, Browne, ML, Druschel, CM, Romitti, PA, Schmidt, RJ, Burns, TL, Moslehi, R & Olney, RS 2012, 'Maternal caffeine consumption and risk of congenital limb deficiencies', Birth Defects Research Part A - Clinical and Molecular Teratology, vol. 94, no. 12, pp. 1033-1043. https://doi.org/10.1002/bdra.23050
Chen, Lei ; Bell, Erin M. ; Browne, Marilyn L. ; Druschel, Charlotte M. ; Romitti, Paul A. ; Schmidt, Rebecca Jean ; Burns, Trudy L. ; Moslehi, Roxana ; Olney, Richard S. / Maternal caffeine consumption and risk of congenital limb deficiencies. In: Birth Defects Research Part A - Clinical and Molecular Teratology. 2012 ; Vol. 94, No. 12. pp. 1033-1043.
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