Maternal brown fat metabolism returns to control level by four weeks postweaning in rats

B. J. Moore, T. Inokuchi, Barbara A Horwitz, J. Stern

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

We studied body composition, white and brown adipose tissue cellularity, lipoprotein lipase activity and metabolic enzyme activity in three groups of rats: nonpregnant controls, lactating dams and nonlactating dams (i.e., dams not permitted to suckle their young). Nine to 11 rats in each group were killed on d 12 postpartum (study d 34) and on d 40 postpartum (study d 62). During lactation, brown fat citrate synthase, β-hydroxyacylCoA dehydrogenase (HOAD) and lipoprotein lipase activities were significantly lower in the lactating than in the nonlactating dams or virgin controls. Although the nonlactating dams had their pups removed within 24 h after delivery, by d 12 postpartum citrate synthase and HOAD activities were significantly lower than those of nonpregnant controls. By the end of the study there were no differences among the three groups except in the case of HOAD. HOAD activity in the lactation group was significantly lower than in the nonlactation group. White fat cell number in the parametrial depot was significantly increased in the nonlactation groups by d 12 postpartum. In the lactation group, increased white fat cell number in this depot was detectable at d 40 postpartum, when carcass fat stores and fat cells had been repleted. These results demonstrate that both lactating and nonlactating dams undergo cellular hyperplasia, at least in the parametrial depot. This may predispose them to obesity. Also, decreased brown fat metabolism in the nonlactating dams may be contributing to their significantly greater carcass fat content at d 12 postpartum.

Original languageEnglish (US)
Pages (from-to)1992-1998
Number of pages7
JournalJournal of Nutrition
Volume119
Issue number12
StatePublished - 1989

Fingerprint

white adipose tissue
Brown Adipose Tissue
brown adipose tissue
adipocytes
lipid metabolism
Postpartum Period
citrate (si)-synthase
lipoprotein lipase
lactation
Mothers
rats
Oxidoreductases
White Adipocytes
Lactation
Citrate (si)-Synthase
Lipoprotein Lipase
hyperplasia
pups
body composition
obesity

Keywords

  • brown fat
  • carcass composition
  • female rats
  • Food intake
  • lactation

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

Moore, B. J., Inokuchi, T., Horwitz, B. A., & Stern, J. (1989). Maternal brown fat metabolism returns to control level by four weeks postweaning in rats. Journal of Nutrition, 119(12), 1992-1998.

Maternal brown fat metabolism returns to control level by four weeks postweaning in rats. / Moore, B. J.; Inokuchi, T.; Horwitz, Barbara A; Stern, J.

In: Journal of Nutrition, Vol. 119, No. 12, 1989, p. 1992-1998.

Research output: Contribution to journalArticle

Moore, BJ, Inokuchi, T, Horwitz, BA & Stern, J 1989, 'Maternal brown fat metabolism returns to control level by four weeks postweaning in rats', Journal of Nutrition, vol. 119, no. 12, pp. 1992-1998.
Moore, B. J. ; Inokuchi, T. ; Horwitz, Barbara A ; Stern, J. / Maternal brown fat metabolism returns to control level by four weeks postweaning in rats. In: Journal of Nutrition. 1989 ; Vol. 119, No. 12. pp. 1992-1998.
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