Maternal autoantibodies in autism spectrum disorder

Karen L. Jones, Judith A Van de Water

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Despite increasing prevalence rates of autism spectrum disorder (ASD) globally, the underlying causes of the disorder have yet to be identifi ed. However, immune dysregulation has been reported in some individuals with ASD as well as in their family members. In particular, IgG antibodies reactive to fetal brain proteins have been reported in a subset of mothers of children with ASD by several investigators. This chapter provides a summary of the research conducted on these maternal autoantibodies and their potential role in the development of ASD. In this chapter, we will explore the current research on maternal autoantibodies as well as potential therapeutic strategies that may be developed for this subset of ASD.

Original languageEnglish (US)
Title of host publicationFrontiers in Autism Research: New Horizons for Diagnosis and Treatment
PublisherWorld Scientific Publishing Co.
Pages429-449
Number of pages21
ISBN (Electronic)9789814602167
ISBN (Print)9789814602150
DOIs
StatePublished - Jan 1 2014

Keywords

  • Autoantibodies
  • Fetal brain proteins
  • Maternal immunity
  • Neuroimmunology

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)
  • Neuroscience(all)

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  • Cite this

    Jones, K. L., & Van de Water, J. A. (2014). Maternal autoantibodies in autism spectrum disorder. In Frontiers in Autism Research: New Horizons for Diagnosis and Treatment (pp. 429-449). World Scientific Publishing Co.. https://doi.org/10.1142/9789814602167_0017