Maternal autoantibodies in autism.

Daniel Braunschweig, Judy Van de Water

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

As epidemiologic studies continue to note a striking increase in rates of autism spectrum disorder (ASD) diagnosis around the world, the lack of identified causative agents in most cases remains a major hindrance to the development of treatment and prevention strategies. Published observations of immune system abnormalities in ASD have increased recently, with several groups identifying fetal protein reactive IgG antibodies in plasma from mothers of children with autism. Furthermore, other gestational immune parameters, including maternal infection and dysregulated cytokine signaling, have been found to be associated with ASD in some cases. While detailed pathogenic mechanisms remain to be determined, the hypothesis that some cases of ASD may be influenced, or even caused, by maternal fetal brain-reactive antibodies or other in utero immune-related exposures is an active area of investigation. This article reviews the current literature in this area and proposes several directions for future research.

Original languageEnglish (US)
Pages (from-to)693-699
Number of pages7
JournalArchives of Neurology
Volume69
Issue number6
StatePublished - Jun 2012

Fingerprint

Autistic Disorder
Autoantibodies
Mothers
Fetal Proteins
Antibodies
Epidemiologic Studies
Immune System
Immunoglobulin G
Cytokines
Autism Spectrum Disorder
Autism Spectrum Disorders
Autism
Brain
Infection
Therapeutics

ASJC Scopus subject areas

  • Clinical Neurology
  • Arts and Humanities (miscellaneous)

Cite this

Maternal autoantibodies in autism. / Braunschweig, Daniel; Van de Water, Judy.

In: Archives of Neurology, Vol. 69, No. 6, 06.2012, p. 693-699.

Research output: Contribution to journalArticle

Braunschweig, D & Van de Water, J 2012, 'Maternal autoantibodies in autism.', Archives of Neurology, vol. 69, no. 6, pp. 693-699.
Braunschweig, Daniel ; Van de Water, Judy. / Maternal autoantibodies in autism. In: Archives of Neurology. 2012 ; Vol. 69, No. 6. pp. 693-699.
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