Abstract
A murine passive transfer model system was employed to ascertain the effects of gestational exposure to a single, intravenous dose of purified, brain-reactive IgG antibodies from individual mothers of children with autism (MAU) or mothers with typically developing children (MTD). Growth and behavioral outcomes in offspring were measured from postnatal days 8 to 65 in each group. Comparisons revealed alterations in early growth trajectories, significantly impaired motor and sensory development, and increased anxiety. This report demonstrates for the first time the effects of a single, low dose gestational exposure of IgG derived from individual MAU on their offspring's physical and social development.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 56-65 |
| Number of pages | 10 |
| Journal | Journal of Neuroimmunology |
| Volume | 252 |
| Issue number | 1-2 |
| DOIs | |
| State | Published - Nov 14 2012 |
Keywords
- Autism
- Immune
- Maternal antibodies
- Mouse behavior
- Passive transfer
ASJC Scopus subject areas
- Immunology
- Clinical Neurology
- Immunology and Allergy
- Neurology
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Braunschweig, D., Golub, M. S., Koenig, C. M., Qi, L., Pessah, I. N., Van de Water, J. A., & Berman, R. F. (2012). Maternal autism-associated IgG antibodies delay development and produce anxiety in a mouse gestational transfer model. Journal of Neuroimmunology, 252(1-2), 56-65. https://doi.org/10.1016/j.jneuroim.2012.08.002