Maternal autism-associated IgG antibodies delay development and produce anxiety in a mouse gestational transfer model

Daniel Braunschweig; Mari S. Golub; Claire M. Koenig; Lihong Qi; Isaac N Pessah; Judith A Van de Water; Robert F Berman

doi:10.1016/j.jneuroim.2012.08.002

Maternal autism-associated IgG antibodies delay development and produce anxiety in a mouse gestational transfer model

Daniel Braunschweig, Mari S. Golub, Claire M. Koenig, Lihong Qi, Isaac N Pessah, Judith A Van de Water, Robert F Berman

Research output: Contribution to journal › Article

43 Scopus citations

Abstract

A murine passive transfer model system was employed to ascertain the effects of gestational exposure to a single, intravenous dose of purified, brain-reactive IgG antibodies from individual mothers of children with autism (MAU) or mothers with typically developing children (MTD). Growth and behavioral outcomes in offspring were measured from postnatal days 8 to 65 in each group. Comparisons revealed alterations in early growth trajectories, significantly impaired motor and sensory development, and increased anxiety. This report demonstrates for the first time the effects of a single, low dose gestational exposure of IgG derived from individual MAU on their offspring's physical and social development.

Original language	English (US)
Pages (from-to)	56-65
Number of pages	10
Journal	Journal of Neuroimmunology
Volume	252
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jneuroim.2012.08.002
State	Published - Nov 14 2012

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Keywords

Autism
Immune
Maternal antibodies
Mouse behavior
Passive transfer

ASJC Scopus subject areas

Immunology
Clinical Neurology
Immunology and Allergy
Neurology

Cite this

Braunschweig, D., Golub, M. S., Koenig, C. M., Qi, L., Pessah, I. N., Van de Water, J. A., & Berman, R. F. (2012). Maternal autism-associated IgG antibodies delay development and produce anxiety in a mouse gestational transfer model. Journal of Neuroimmunology, 252(1-2), 56-65. https://doi.org/10.1016/j.jneuroim.2012.08.002

Maternal autism-associated IgG antibodies delay development and produce anxiety in a mouse gestational transfer model. / Braunschweig, Daniel; Golub, Mari S.; Koenig, Claire M.; Qi, Lihong ; Pessah, Isaac N ; Van de Water, Judith A ; Berman, Robert F.

In: Journal of Neuroimmunology, Vol. 252, No. 1-2, 14.11.2012, p. 56-65.

Research output: Contribution to journal › Article

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10.1016/j.jneuroim.2012.08.002