Abstract
A murine passive transfer model system was employed to ascertain the effects of gestational exposure to a single, intravenous dose of purified, brain-reactive IgG antibodies from individual mothers of children with autism (MAU) or mothers with typically developing children (MTD). Growth and behavioral outcomes in offspring were measured from postnatal days 8 to 65 in each group. Comparisons revealed alterations in early growth trajectories, significantly impaired motor and sensory development, and increased anxiety. This report demonstrates for the first time the effects of a single, low dose gestational exposure of IgG derived from individual MAU on their offspring's physical and social development.
Original language | English (US) |
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Pages (from-to) | 56-65 |
Number of pages | 10 |
Journal | Journal of Neuroimmunology |
Volume | 252 |
Issue number | 1-2 |
DOIs | |
State | Published - Nov 14 2012 |
Keywords
- Autism
- Immune
- Maternal antibodies
- Mouse behavior
- Passive transfer
ASJC Scopus subject areas
- Immunology
- Clinical Neurology
- Immunology and Allergy
- Neurology