Maternal autism-associated IgG antibodies delay development and produce anxiety in a mouse gestational transfer model

Daniel Braunschweig; Mari S. Golub; Claire M. Koenig; Lihong Qi; Isaac N Pessah; Judith A Van de Water; Robert F Berman

doi:10.1016/j.jneuroim.2012.08.002

Maternal autism-associated IgG antibodies delay development and produce anxiety in a mouse gestational transfer model

Daniel Braunschweig, Mari S. Golub, Claire M. Koenig, Lihong Qi, Isaac N Pessah, Judith A Van de Water, Robert F Berman

Research output: Contribution to journal › Article › peer-review

48 Scopus citations

Abstract

A murine passive transfer model system was employed to ascertain the effects of gestational exposure to a single, intravenous dose of purified, brain-reactive IgG antibodies from individual mothers of children with autism (MAU) or mothers with typically developing children (MTD). Growth and behavioral outcomes in offspring were measured from postnatal days 8 to 65 in each group. Comparisons revealed alterations in early growth trajectories, significantly impaired motor and sensory development, and increased anxiety. This report demonstrates for the first time the effects of a single, low dose gestational exposure of IgG derived from individual MAU on their offspring's physical and social development.

Original language	English (US)
Pages (from-to)	56-65
Number of pages	10
Journal	Journal of Neuroimmunology
Volume	252
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jneuroim.2012.08.002
State	Published - Nov 14 2012

Keywords

Autism
Immune
Maternal antibodies
Mouse behavior
Passive transfer

ASJC Scopus subject areas

Immunology
Clinical Neurology
Immunology and Allergy
Neurology

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10.1016/j.jneuroim.2012.08.002

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Maternal autism-associated IgG antibodies delay development and produce anxiety in a mouse gestational transfer model. / Braunschweig, Daniel; Golub, Mari S.; Koenig, Claire M.; Qi, Lihong ; Pessah, Isaac N ; Van de Water, Judith A ; Berman, Robert F.

In: Journal of Neuroimmunology, Vol. 252, No. 1-2, 14.11.2012, p. 56-65.

Research output: Contribution to journal › Article › peer-review

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Maternal autism-associated IgG antibodies delay development and produce anxiety in a mouse gestational transfer model

Abstract

Keywords

ASJC Scopus subject areas

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