Maternal autism-associated IgG antibodies delay development and produce anxiety in a mouse gestational transfer model

Daniel Braunschweig, Mari S. Golub, Claire M. Koenig, Lihong Qi, Isaac N Pessah, Judith A Van de Water, Robert F Berman

Research output: Contribution to journalArticle

43 Scopus citations

Abstract

A murine passive transfer model system was employed to ascertain the effects of gestational exposure to a single, intravenous dose of purified, brain-reactive IgG antibodies from individual mothers of children with autism (MAU) or mothers with typically developing children (MTD). Growth and behavioral outcomes in offspring were measured from postnatal days 8 to 65 in each group. Comparisons revealed alterations in early growth trajectories, significantly impaired motor and sensory development, and increased anxiety. This report demonstrates for the first time the effects of a single, low dose gestational exposure of IgG derived from individual MAU on their offspring's physical and social development.

Original languageEnglish (US)
Pages (from-to)56-65
Number of pages10
JournalJournal of Neuroimmunology
Volume252
Issue number1-2
DOIs
StatePublished - Nov 14 2012

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Keywords

  • Autism
  • Immune
  • Maternal antibodies
  • Mouse behavior
  • Passive transfer

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Immunology and Allergy
  • Neurology

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