Maternal and fetal pharmacokinetics of oral radiolabeled and authentic bisphenol a in the rhesus monkey

Catherine A. VandeVoort, Roy R. Gerona, Frederick S. Vom Saal, Alice F Tarantal, Patricia A. Hunt, Anne Hillenweck, Daniel Zalko

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The present study was conducted in pregnant rhesus monkeys to determine the rapidity and extent to which BPA reaches the fetal compartment following oral ingestion, and the 24-hr fate of BPA. To assess metabolism changes during the course of pregnancy, we compared BPA biotransformation during the second and third trimesters in the same animals, measuring the levels of sulfated, gluronidated, and free BPA in maternal serum, amniotic fluid, and fetal serum. All animals showed measurable unconjugated and conjugated BPA in the fetal compartment and slow clearance compared to maternal serum. There were higher levels of BPA-G in amniotic fluid at 150 days gestation compared to 100 days gestation, as well as higher levels of BPA-G than BPA-S. We also monitored 3H-BPA (and metabolites) in key tissues and excreta from a mother and fetus and from a non-pregnant female. The elimination of radioactivity was rapid, but residues were still detectable 24 hr after dosing in all tissues analyzed. These data suggest that, in primates, rapid maternal processing of BPA does not alleviate the risk of exposure to the developing fetus. This study elevates concerns about levels of current BPA human exposure from potentially a large number of unknown sources and the risks posed to developing fetuses.

Original languageEnglish (US)
Article numbere0165410
JournalPLoS One
Volume11
Issue number12
DOIs
StatePublished - Dec 1 2016

Fingerprint

Pharmacokinetics
Macaca mulatta
pharmacokinetics
fetus
amniotic fluid
mouth
Animals
Fetus
Mothers
pregnancy
Amniotic Fluid
Tissue
Pregnancy
Fluids
Radioactivity
Metabolites
Serum
Metabolism
Third Pregnancy Trimester
Second Pregnancy Trimester

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

VandeVoort, C. A., Gerona, R. R., Vom Saal, F. S., Tarantal, A. F., Hunt, P. A., Hillenweck, A., & Zalko, D. (2016). Maternal and fetal pharmacokinetics of oral radiolabeled and authentic bisphenol a in the rhesus monkey. PLoS One, 11(12), [e0165410]. https://doi.org/10.1371/journal.pone.0165410

Maternal and fetal pharmacokinetics of oral radiolabeled and authentic bisphenol a in the rhesus monkey. / VandeVoort, Catherine A.; Gerona, Roy R.; Vom Saal, Frederick S.; Tarantal, Alice F; Hunt, Patricia A.; Hillenweck, Anne; Zalko, Daniel.

In: PLoS One, Vol. 11, No. 12, e0165410, 01.12.2016.

Research output: Contribution to journalArticle

VandeVoort, CA, Gerona, RR, Vom Saal, FS, Tarantal, AF, Hunt, PA, Hillenweck, A & Zalko, D 2016, 'Maternal and fetal pharmacokinetics of oral radiolabeled and authentic bisphenol a in the rhesus monkey', PLoS One, vol. 11, no. 12, e0165410. https://doi.org/10.1371/journal.pone.0165410
VandeVoort, Catherine A. ; Gerona, Roy R. ; Vom Saal, Frederick S. ; Tarantal, Alice F ; Hunt, Patricia A. ; Hillenweck, Anne ; Zalko, Daniel. / Maternal and fetal pharmacokinetics of oral radiolabeled and authentic bisphenol a in the rhesus monkey. In: PLoS One. 2016 ; Vol. 11, No. 12.
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