Abstract
Cell-based therapies are a promising alternative to grafts and organ transplantation for treating tissue loss or damage due to trauma, malfunction, or disease. Over the past two decades, mesenchymal stem cells (MSCs) have attracted much attention as a potential cell population for use in regenerative medicine. Although the proliferative capacity and multilineage potential of MSCs provide an opportunity to generate clinically relevant numbers of transplantable cells, their use in tissue regenerative applications has met with relatively limited success to date apart from secreting paracrine-acting factors to modulate the defect microenvironment. Presently, there is significant effort to engineer the biophysical properties of biomaterials to direct MSC differentiation and further expand on the potential of MSCs in tissue engineering, regeneration, and repair. Biomaterials can dictate MSC differentiation by modulating features of the substrate including composition, mechanical properties, porosity, and topography. The purpose of this review is to highlight recent approaches for guiding MSC fate using biomaterials and provide a description of the underlying characteristics that promote differentiation toward a desired phenotype.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1115-1127 |
| Number of pages | 13 |
| Journal | ACS Biomaterials Science and Engineering |
| Volume | 4 |
| Issue number | 4 |
| DOIs | |
| State | Published - Apr 9 2018 |
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Keywords
- biomaterial
- differentiation
- mesenchymal stem cell
- scaffold
- tissue engineering
ASJC Scopus subject areas
- Biomaterials
- Biomedical Engineering
Cite this
Materials-Directed Differentiation of Mesenchymal Stem Cells for Tissue Engineering and Regeneration. / Leach, Jonathan K; Whitehead, Jacklyn.
In: ACS Biomaterials Science and Engineering, Vol. 4, No. 4, 09.04.2018, p. 1115-1127.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Materials-Directed Differentiation of Mesenchymal Stem Cells for Tissue Engineering and Regeneration
AU - Leach, Jonathan K
AU - Whitehead, Jacklyn
PY - 2018/4/9
Y1 - 2018/4/9
N2 - Cell-based therapies are a promising alternative to grafts and organ transplantation for treating tissue loss or damage due to trauma, malfunction, or disease. Over the past two decades, mesenchymal stem cells (MSCs) have attracted much attention as a potential cell population for use in regenerative medicine. Although the proliferative capacity and multilineage potential of MSCs provide an opportunity to generate clinically relevant numbers of transplantable cells, their use in tissue regenerative applications has met with relatively limited success to date apart from secreting paracrine-acting factors to modulate the defect microenvironment. Presently, there is significant effort to engineer the biophysical properties of biomaterials to direct MSC differentiation and further expand on the potential of MSCs in tissue engineering, regeneration, and repair. Biomaterials can dictate MSC differentiation by modulating features of the substrate including composition, mechanical properties, porosity, and topography. The purpose of this review is to highlight recent approaches for guiding MSC fate using biomaterials and provide a description of the underlying characteristics that promote differentiation toward a desired phenotype.
AB - Cell-based therapies are a promising alternative to grafts and organ transplantation for treating tissue loss or damage due to trauma, malfunction, or disease. Over the past two decades, mesenchymal stem cells (MSCs) have attracted much attention as a potential cell population for use in regenerative medicine. Although the proliferative capacity and multilineage potential of MSCs provide an opportunity to generate clinically relevant numbers of transplantable cells, their use in tissue regenerative applications has met with relatively limited success to date apart from secreting paracrine-acting factors to modulate the defect microenvironment. Presently, there is significant effort to engineer the biophysical properties of biomaterials to direct MSC differentiation and further expand on the potential of MSCs in tissue engineering, regeneration, and repair. Biomaterials can dictate MSC differentiation by modulating features of the substrate including composition, mechanical properties, porosity, and topography. The purpose of this review is to highlight recent approaches for guiding MSC fate using biomaterials and provide a description of the underlying characteristics that promote differentiation toward a desired phenotype.
KW - biomaterial
KW - differentiation
KW - mesenchymal stem cell
KW - scaffold
KW - tissue engineering
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UR - http://www.scopus.com/inward/citedby.url?scp=85045211736&partnerID=8YFLogxK
U2 - 10.1021/acsbiomaterials.6b00741
DO - 10.1021/acsbiomaterials.6b00741
M3 - Review article
AN - SCOPUS:85045211736
VL - 4
SP - 1115
EP - 1127
JO - ACS Biomaterials Science and Engineering
JF - ACS Biomaterials Science and Engineering
SN - 2373-9878
IS - 4
ER -