Mast cells and immunological skin diseases

Daniel Navi, Jun Saegusa, Fu-Tong Liu

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

Mast cells play an important role in both adaptive and innate immunity, and a large body of literature demonstrates their functions in skin immunity. This article reviews the literature on the role of this cell type in the pathogenesis of a number of immunological skin diseases, including contact dermatitis, atopic dermatitis, immunobullous disease, scleroderma, and chronic graft-vs.-host disease. In all these diseases, mast cells are noted to increase in number and undergo degranulation in the affected skin, and in some cases, their specific mediators are detected. Elucidation of the contribution of mast cells to the pathogenesis of these diseases has been aided significantly by the use of animal models, especially mouse models. The studies of mast cell-deficient mice in conjunction with normal congenic mice have been particularly fruitful, although in some cases, such as contact dermatitis, a definitive conclusion has not been achieved despite extensive efforts. The role of mast cells in atopic dermatitis has also been suggested by studies of gene polymorphism, which have linked some of the mast cell-related genes to the disease. In the case of scleroderma and chronic graft-vs.-host disease, the function of mast cells in fibrosis is further supported by the ability of these cells and their mediators to induce activation and proliferation of fibroblasts. Therapies targeting mast cells may prove beneficial for treatment of these inflammatory and autoimmune diseases.

Original languageEnglish (US)
Pages (from-to)144-155
Number of pages12
JournalClinical Reviews in Allergy and Immunology
Volume33
Issue number1-2
DOIs
StatePublished - Oct 2007

Fingerprint

Immune System Diseases
Skin Diseases
Mast Cells
Contact Dermatitis
Atopic Dermatitis
Mastocytosis
Congenic Mice
Transplants
Skin
Adaptive Immunity
Innate Immunity
Genes
Autoimmune Diseases
Immunity
Fibrosis
Chronic Disease
Animal Models
Fibroblasts

Keywords

  • Atopic dermatitis
  • Bullous pemphigoid
  • Contact dermatitis
  • Graft-vs.-host disease
  • IgE
  • Mast cells
  • Scleroderma

ASJC Scopus subject areas

  • Immunology and Allergy

Cite this

Mast cells and immunological skin diseases. / Navi, Daniel; Saegusa, Jun; Liu, Fu-Tong.

In: Clinical Reviews in Allergy and Immunology, Vol. 33, No. 1-2, 10.2007, p. 144-155.

Research output: Contribution to journalArticle

Navi, Daniel ; Saegusa, Jun ; Liu, Fu-Tong. / Mast cells and immunological skin diseases. In: Clinical Reviews in Allergy and Immunology. 2007 ; Vol. 33, No. 1-2. pp. 144-155.
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