Mast cells and histamine alter intestinal permeability during malaria parasite infection

Rashaun A. Potts, Caitlin M. Tiffany, Nazzy Pakpour, Kristen L. Lokken, Connor R. Tiffany, Kong Cheung, Renee M Tsolis, Shirley Luckhart

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Co-infections with malaria and non-typhoidal Salmonella serotypes (NTS) can present as life-threatening bacteremia, in contrast to self-resolving NTS diarrhea in healthy individuals. In previous work with our mouse model of malaria/NTS co-infection, we showed increased gut mastocytosis and increased ileal and plasma histamine levels that were temporally associated with increased gut permeability and bacterial translocation. Here, we report that gut mastocytosis and elevated plasma histamine are also associated with malaria in an animal model of falciparum malaria, suggesting a broader host distribution of this biology. In support of mast cell function in this phenotype, malaria/NTS co-infection in mast cell-deficient mice was associated with a reduction in gut permeability and bacteremia. Further, antihistamine treatment reduced bacterial translocation and gut permeability in mice with malaria, suggesting a contribution of mast cell-derived histamine to GI pathology and enhanced risk of bacteremia during malaria/NTS co-infection.

Original languageEnglish (US)
JournalImmunobiology
DOIs
StateAccepted/In press - Aug 9 2015

Fingerprint

Parasitic Diseases
Mast Cells
Histamine
Malaria
Permeability
Salmonella
Coinfection
Bacteremia
Mastocytosis
Bacterial Translocation
Falciparum Malaria
Histamine Antagonists
Diarrhea
Animal Models
Serogroup
Pathology
Phenotype

Keywords

  • Bacteremia
  • Co-infection
  • Histamine
  • Malaria
  • Mast cell
  • Plasmodium
  • Salmonella

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Hematology

Cite this

Potts, R. A., Tiffany, C. M., Pakpour, N., Lokken, K. L., Tiffany, C. R., Cheung, K., ... Luckhart, S. (Accepted/In press). Mast cells and histamine alter intestinal permeability during malaria parasite infection. Immunobiology. https://doi.org/10.1016/j.imbio.2015.11.003

Mast cells and histamine alter intestinal permeability during malaria parasite infection. / Potts, Rashaun A.; Tiffany, Caitlin M.; Pakpour, Nazzy; Lokken, Kristen L.; Tiffany, Connor R.; Cheung, Kong; Tsolis, Renee M; Luckhart, Shirley.

In: Immunobiology, 09.08.2015.

Research output: Contribution to journalArticle

Potts, Rashaun A. ; Tiffany, Caitlin M. ; Pakpour, Nazzy ; Lokken, Kristen L. ; Tiffany, Connor R. ; Cheung, Kong ; Tsolis, Renee M ; Luckhart, Shirley. / Mast cells and histamine alter intestinal permeability during malaria parasite infection. In: Immunobiology. 2015.
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