Massive number of antigen-specific CD4 T cells during vaccination with live attenuated Salmonella causes interclonal competition

Aparna Srinivasan, Joseph Foley, Stephen J Mcsorley

Research output: Contribution to journalArticle

51 Scopus citations


The clonal burst size of CD4 T cells is predicted to be less than that of CD8 T cells. In this study, we demonstrate that massive numbers of Ag-specific CD4 T cells respond during vaccination of mice with live attenuated Salmonella, reaching a peak frequency of ∼50% of CD4 T cells. Salmonella-specific T cells persisted at high frequency for several weeks and could be detected in the memory population for months after infection. Surprisingly, the expansion of endogenous Salmonella-specific CD4 T cells prevented the persistence of adoptively transferred Salmonella-specific T cells in vivo, demonstrating interclonal competition for access to the memory compartment.

Original languageEnglish (US)
Pages (from-to)6884-6893
Number of pages10
JournalJournal of Immunology
Issue number11
StatePublished - Jun 1 2004
Externally publishedYes


ASJC Scopus subject areas

  • Immunology

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