Abstract
The clonal burst size of CD4 T cells is predicted to be less than that of CD8 T cells. In this study, we demonstrate that massive numbers of Ag-specific CD4 T cells respond during vaccination of mice with live attenuated Salmonella, reaching a peak frequency of ∼50% of CD4 T cells. Salmonella-specific T cells persisted at high frequency for several weeks and could be detected in the memory population for months after infection. Surprisingly, the expansion of endogenous Salmonella-specific CD4 T cells prevented the persistence of adoptively transferred Salmonella-specific T cells in vivo, demonstrating interclonal competition for access to the memory compartment.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 6884-6893 |
| Number of pages | 10 |
| Journal | Journal of Immunology |
| Volume | 172 |
| Issue number | 11 |
| State | Published - Jun 1 2004 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Immunology
Cite this
Massive number of antigen-specific CD4 T cells during vaccination with live attenuated Salmonella causes interclonal competition. / Srinivasan, Aparna; Foley, Joseph; Mcsorley, Stephen J.
In: Journal of Immunology, Vol. 172, No. 11, 01.06.2004, p. 6884-6893.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Massive number of antigen-specific CD4 T cells during vaccination with live attenuated Salmonella causes interclonal competition
AU - Srinivasan, Aparna
AU - Foley, Joseph
AU - Mcsorley, Stephen J
PY - 2004/6/1
Y1 - 2004/6/1
N2 - The clonal burst size of CD4 T cells is predicted to be less than that of CD8 T cells. In this study, we demonstrate that massive numbers of Ag-specific CD4 T cells respond during vaccination of mice with live attenuated Salmonella, reaching a peak frequency of ∼50% of CD4 T cells. Salmonella-specific T cells persisted at high frequency for several weeks and could be detected in the memory population for months after infection. Surprisingly, the expansion of endogenous Salmonella-specific CD4 T cells prevented the persistence of adoptively transferred Salmonella-specific T cells in vivo, demonstrating interclonal competition for access to the memory compartment.
AB - The clonal burst size of CD4 T cells is predicted to be less than that of CD8 T cells. In this study, we demonstrate that massive numbers of Ag-specific CD4 T cells respond during vaccination of mice with live attenuated Salmonella, reaching a peak frequency of ∼50% of CD4 T cells. Salmonella-specific T cells persisted at high frequency for several weeks and could be detected in the memory population for months after infection. Surprisingly, the expansion of endogenous Salmonella-specific CD4 T cells prevented the persistence of adoptively transferred Salmonella-specific T cells in vivo, demonstrating interclonal competition for access to the memory compartment.
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UR - http://www.scopus.com/inward/citedby.url?scp=2442706543&partnerID=8YFLogxK
M3 - Article
VL - 172
SP - 6884
EP - 6893
JO - Journal of Immunology
JF - Journal of Immunology
SN - 0022-1767
IS - 11
ER -