Mass vaccination campaign against rabies: are dogs correctly protected? The Peruvian experience.

Bruno B Chomel, G. Chappuis, F. Bullon, E. Cardenas, T. D. de Beublain, M. Lombard, E. Giambruno

Research output: Contribution to journalArticlepeer-review

47 Scopus citations

Abstract

In a mass vaccination campaign conducted in Peru in March 1985, 270,000 dogs (65% of the estimated dog population) were vaccinated over the course of 1 month with an inactivated tissue culture vaccine. Since that time no human rabies cases have been reported; in addition, the number of animal rabies cases has declined to only three from a previous mean of 292 cases per year since 1980. A serologic survey was also done to determine the immune response among randomly selected vaccinated dogs, with titers determined 3, 6, 9, and 12 months after vaccination. Twelve months after vaccination, 97% of the dogs had a rabies neutralizing antibody titer of greater than or equal to 0.5 IU/mL, and 87% had a titer of greater than or equal to 1.0 IU/mL. Thus, this tissue culture rabies vaccine given under field conditions induced antibodies that lasted for at least 1 year in 97% of vaccinated dogs.

Original languageEnglish (US)
JournalReviews of Infectious Diseases
Volume10 Suppl 4
StatePublished - Nov 1988
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology (medical)

Fingerprint Dive into the research topics of 'Mass vaccination campaign against rabies: are dogs correctly protected? The Peruvian experience.'. Together they form a unique fingerprint.

Cite this