Abstract
Voltage-gated sodium and potassium channels underlie electrical activity of neurons, and are dynamically regulated by diverse cell signaling pathways that ultimately exert their effects by altering the phosphorylation state of channel subunits. Recent mass spectrometric-based studies have led to a new appreciation of the extent and nature of phosphorylation of these ion channels in mammalian brain. This has allowed for new insights into how neurons dynamically regulate the localization, activity and expression through multisite ion channel phosphorylation.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 153-159 |
| Number of pages | 7 |
| Journal | Seminars in Cell and Developmental Biology |
| Volume | 22 |
| Issue number | 2 |
| DOIs | |
| State | Published - Apr 2011 |
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Keywords
- Brain ion channel
- Mass spectrometry
- Phosphoproteomics
- VGKC (Kv channel)
- VGSC (Nav channel)
ASJC Scopus subject areas
- Developmental Biology
- Cell Biology
Cite this
Mass spectrometry-based phosphoproteomics reveals multisite phosphorylation on mammalian brain voltage-gated sodium and potassium channels. / Baek, Je Hyun; Cerda, Oscar; Trimmer, James.
In: Seminars in Cell and Developmental Biology, Vol. 22, No. 2, 04.2011, p. 153-159.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Mass spectrometry-based phosphoproteomics reveals multisite phosphorylation on mammalian brain voltage-gated sodium and potassium channels
AU - Baek, Je Hyun
AU - Cerda, Oscar
AU - Trimmer, James
PY - 2011/4
Y1 - 2011/4
N2 - Voltage-gated sodium and potassium channels underlie electrical activity of neurons, and are dynamically regulated by diverse cell signaling pathways that ultimately exert their effects by altering the phosphorylation state of channel subunits. Recent mass spectrometric-based studies have led to a new appreciation of the extent and nature of phosphorylation of these ion channels in mammalian brain. This has allowed for new insights into how neurons dynamically regulate the localization, activity and expression through multisite ion channel phosphorylation.
AB - Voltage-gated sodium and potassium channels underlie electrical activity of neurons, and are dynamically regulated by diverse cell signaling pathways that ultimately exert their effects by altering the phosphorylation state of channel subunits. Recent mass spectrometric-based studies have led to a new appreciation of the extent and nature of phosphorylation of these ion channels in mammalian brain. This has allowed for new insights into how neurons dynamically regulate the localization, activity and expression through multisite ion channel phosphorylation.
KW - Brain ion channel
KW - Mass spectrometry
KW - Phosphoproteomics
KW - VGKC (Kv channel)
KW - VGSC (Nav channel)
UR - http://www.scopus.com/inward/record.url?scp=79952419012&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79952419012&partnerID=8YFLogxK
U2 - 10.1016/j.semcdb.2010.09.009
DO - 10.1016/j.semcdb.2010.09.009
M3 - Article
C2 - 20932926
AN - SCOPUS:79952419012
VL - 22
SP - 153
EP - 159
JO - Seminars in Cell and Developmental Biology
JF - Seminars in Cell and Developmental Biology
SN - 1084-9521
IS - 2
ER -