Mass spectrometry-based phosphoproteomics reveals multisite phosphorylation on mammalian brain voltage-gated sodium and potassium channels

Je Hyun Baek, Oscar Cerda, James Trimmer

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

Voltage-gated sodium and potassium channels underlie electrical activity of neurons, and are dynamically regulated by diverse cell signaling pathways that ultimately exert their effects by altering the phosphorylation state of channel subunits. Recent mass spectrometric-based studies have led to a new appreciation of the extent and nature of phosphorylation of these ion channels in mammalian brain. This has allowed for new insights into how neurons dynamically regulate the localization, activity and expression through multisite ion channel phosphorylation.

Original languageEnglish (US)
Pages (from-to)153-159
Number of pages7
JournalSeminars in Cell and Developmental Biology
Volume22
Issue number2
DOIs
StatePublished - Apr 2011

Keywords

  • Brain ion channel
  • Mass spectrometry
  • Phosphoproteomics
  • VGKC (Kv channel)
  • VGSC (Nav channel)

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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