Abstract
Voltage-gated sodium and potassium channels underlie electrical activity of neurons, and are dynamically regulated by diverse cell signaling pathways that ultimately exert their effects by altering the phosphorylation state of channel subunits. Recent mass spectrometric-based studies have led to a new appreciation of the extent and nature of phosphorylation of these ion channels in mammalian brain. This has allowed for new insights into how neurons dynamically regulate the localization, activity and expression through multisite ion channel phosphorylation.
Original language | English (US) |
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Pages (from-to) | 153-159 |
Number of pages | 7 |
Journal | Seminars in Cell and Developmental Biology |
Volume | 22 |
Issue number | 2 |
DOIs | |
State | Published - Apr 2011 |
Keywords
- Brain ion channel
- Mass spectrometry
- Phosphoproteomics
- VGKC (Kv channel)
- VGSC (Nav channel)
ASJC Scopus subject areas
- Developmental Biology
- Cell Biology