Mass spectrometry-based phosphoproteomics reveals multisite phosphorylation on mammalian brain voltage-gated sodium and potassium channels

Je Hyun Baek, Oscar Cerda, James Trimmer

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Voltage-gated sodium and potassium channels underlie electrical activity of neurons, and are dynamically regulated by diverse cell signaling pathways that ultimately exert their effects by altering the phosphorylation state of channel subunits. Recent mass spectrometric-based studies have led to a new appreciation of the extent and nature of phosphorylation of these ion channels in mammalian brain. This has allowed for new insights into how neurons dynamically regulate the localization, activity and expression through multisite ion channel phosphorylation.

Original languageEnglish (US)
Pages (from-to)153-159
Number of pages7
JournalSeminars in Cell and Developmental Biology
Volume22
Issue number2
DOIs
StatePublished - Apr 2011

Fingerprint

Voltage-Gated Sodium Channels
Voltage-Gated Potassium Channels
Mass Spectrometry
Phosphorylation
Ion Channels
Brain
Neurons

Keywords

  • Brain ion channel
  • Mass spectrometry
  • Phosphoproteomics
  • VGKC (Kv channel)
  • VGSC (Nav channel)

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

Cite this

Mass spectrometry-based phosphoproteomics reveals multisite phosphorylation on mammalian brain voltage-gated sodium and potassium channels. / Baek, Je Hyun; Cerda, Oscar; Trimmer, James.

In: Seminars in Cell and Developmental Biology, Vol. 22, No. 2, 04.2011, p. 153-159.

Research output: Contribution to journalArticle

@article{738e8c524c814b5f87a9c1f307cd74f0,
title = "Mass spectrometry-based phosphoproteomics reveals multisite phosphorylation on mammalian brain voltage-gated sodium and potassium channels",
abstract = "Voltage-gated sodium and potassium channels underlie electrical activity of neurons, and are dynamically regulated by diverse cell signaling pathways that ultimately exert their effects by altering the phosphorylation state of channel subunits. Recent mass spectrometric-based studies have led to a new appreciation of the extent and nature of phosphorylation of these ion channels in mammalian brain. This has allowed for new insights into how neurons dynamically regulate the localization, activity and expression through multisite ion channel phosphorylation.",
keywords = "Brain ion channel, Mass spectrometry, Phosphoproteomics, VGKC (Kv channel), VGSC (Nav channel)",
author = "Baek, {Je Hyun} and Oscar Cerda and James Trimmer",
year = "2011",
month = "4",
doi = "10.1016/j.semcdb.2010.09.009",
language = "English (US)",
volume = "22",
pages = "153--159",
journal = "Seminars in Cell and Developmental Biology",
issn = "1084-9521",
publisher = "Academic Press Inc.",
number = "2",

}

TY - JOUR

T1 - Mass spectrometry-based phosphoproteomics reveals multisite phosphorylation on mammalian brain voltage-gated sodium and potassium channels

AU - Baek, Je Hyun

AU - Cerda, Oscar

AU - Trimmer, James

PY - 2011/4

Y1 - 2011/4

N2 - Voltage-gated sodium and potassium channels underlie electrical activity of neurons, and are dynamically regulated by diverse cell signaling pathways that ultimately exert their effects by altering the phosphorylation state of channel subunits. Recent mass spectrometric-based studies have led to a new appreciation of the extent and nature of phosphorylation of these ion channels in mammalian brain. This has allowed for new insights into how neurons dynamically regulate the localization, activity and expression through multisite ion channel phosphorylation.

AB - Voltage-gated sodium and potassium channels underlie electrical activity of neurons, and are dynamically regulated by diverse cell signaling pathways that ultimately exert their effects by altering the phosphorylation state of channel subunits. Recent mass spectrometric-based studies have led to a new appreciation of the extent and nature of phosphorylation of these ion channels in mammalian brain. This has allowed for new insights into how neurons dynamically regulate the localization, activity and expression through multisite ion channel phosphorylation.

KW - Brain ion channel

KW - Mass spectrometry

KW - Phosphoproteomics

KW - VGKC (Kv channel)

KW - VGSC (Nav channel)

UR - http://www.scopus.com/inward/record.url?scp=79952419012&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79952419012&partnerID=8YFLogxK

U2 - 10.1016/j.semcdb.2010.09.009

DO - 10.1016/j.semcdb.2010.09.009

M3 - Article

C2 - 20932926

AN - SCOPUS:79952419012

VL - 22

SP - 153

EP - 159

JO - Seminars in Cell and Developmental Biology

JF - Seminars in Cell and Developmental Biology

SN - 1084-9521

IS - 2

ER -