Markers of lung disease in exhaled breath

Nitric oxide

Jiyeon Choi, Leslie A. Hoffman, George W Rodway, Jigme M. Sethi

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Management of airway inflammation requires proper monitoring and treatment to improve long-term outcomes. However, achieving this goal is difficult, as current methods have limitations. Although nitric oxide (NO) was first identified 200 years ago, its physiological importance was not recognized until the early 1980s. Many studies have established the role of NO as an essential messenger molecule in body systems. In addition, studies have demonstrated a significant relationship between changes in exhaled NO levels and other markers of airway inflammation. The technique used to measure NO in exhaled breath is noninvasive, reproducible, sensitive, and easy to perform. Consequently, there is growing interest in the use of exhaled NO in the management of asthma and other pulmonary conditions. The purpose of this review is to promote a basic understanding of the physiologic actions of NO, measurement techniques, and ways that research findings might translate to future application in clinical practice. Specifically, the article will review the role of exhaled NO in regard to its historical background, mechanisms of action, measurement techniques, and implications for clinical practice and research.

Original languageEnglish (US)
Pages (from-to)241-255
Number of pages15
JournalBiological Research for Nursing
Volume7
Issue number4
DOIs
StatePublished - Apr 2006
Externally publishedYes

Fingerprint

Lung Diseases
Nitric Oxide
Inflammation
Airway Management
Research Design
Asthma
Lung
Research

Keywords

  • Asthma
  • Chronic obstructive pulmonary diseases
  • Exhaled gas analysis
  • Lung inflammation
  • Lung transplantation
  • Nitric oxide

ASJC Scopus subject areas

  • Research and Theory

Cite this

Markers of lung disease in exhaled breath : Nitric oxide. / Choi, Jiyeon; Hoffman, Leslie A.; Rodway, George W; Sethi, Jigme M.

In: Biological Research for Nursing, Vol. 7, No. 4, 04.2006, p. 241-255.

Research output: Contribution to journalArticle

Choi, Jiyeon ; Hoffman, Leslie A. ; Rodway, George W ; Sethi, Jigme M. / Markers of lung disease in exhaled breath : Nitric oxide. In: Biological Research for Nursing. 2006 ; Vol. 7, No. 4. pp. 241-255.
@article{cbe74fe9512642a192793ee5e7c24551,
title = "Markers of lung disease in exhaled breath: Nitric oxide",
abstract = "Management of airway inflammation requires proper monitoring and treatment to improve long-term outcomes. However, achieving this goal is difficult, as current methods have limitations. Although nitric oxide (NO) was first identified 200 years ago, its physiological importance was not recognized until the early 1980s. Many studies have established the role of NO as an essential messenger molecule in body systems. In addition, studies have demonstrated a significant relationship between changes in exhaled NO levels and other markers of airway inflammation. The technique used to measure NO in exhaled breath is noninvasive, reproducible, sensitive, and easy to perform. Consequently, there is growing interest in the use of exhaled NO in the management of asthma and other pulmonary conditions. The purpose of this review is to promote a basic understanding of the physiologic actions of NO, measurement techniques, and ways that research findings might translate to future application in clinical practice. Specifically, the article will review the role of exhaled NO in regard to its historical background, mechanisms of action, measurement techniques, and implications for clinical practice and research.",
keywords = "Asthma, Chronic obstructive pulmonary diseases, Exhaled gas analysis, Lung inflammation, Lung transplantation, Nitric oxide",
author = "Jiyeon Choi and Hoffman, {Leslie A.} and Rodway, {George W} and Sethi, {Jigme M.}",
year = "2006",
month = "4",
doi = "10.1016/j.chembiol.2005.12.011",
language = "English (US)",
volume = "7",
pages = "241--255",
journal = "Biological Research for Nursing",
issn = "1099-8004",
publisher = "SAGE Publications Inc.",
number = "4",

}

TY - JOUR

T1 - Markers of lung disease in exhaled breath

T2 - Nitric oxide

AU - Choi, Jiyeon

AU - Hoffman, Leslie A.

AU - Rodway, George W

AU - Sethi, Jigme M.

PY - 2006/4

Y1 - 2006/4

N2 - Management of airway inflammation requires proper monitoring and treatment to improve long-term outcomes. However, achieving this goal is difficult, as current methods have limitations. Although nitric oxide (NO) was first identified 200 years ago, its physiological importance was not recognized until the early 1980s. Many studies have established the role of NO as an essential messenger molecule in body systems. In addition, studies have demonstrated a significant relationship between changes in exhaled NO levels and other markers of airway inflammation. The technique used to measure NO in exhaled breath is noninvasive, reproducible, sensitive, and easy to perform. Consequently, there is growing interest in the use of exhaled NO in the management of asthma and other pulmonary conditions. The purpose of this review is to promote a basic understanding of the physiologic actions of NO, measurement techniques, and ways that research findings might translate to future application in clinical practice. Specifically, the article will review the role of exhaled NO in regard to its historical background, mechanisms of action, measurement techniques, and implications for clinical practice and research.

AB - Management of airway inflammation requires proper monitoring and treatment to improve long-term outcomes. However, achieving this goal is difficult, as current methods have limitations. Although nitric oxide (NO) was first identified 200 years ago, its physiological importance was not recognized until the early 1980s. Many studies have established the role of NO as an essential messenger molecule in body systems. In addition, studies have demonstrated a significant relationship between changes in exhaled NO levels and other markers of airway inflammation. The technique used to measure NO in exhaled breath is noninvasive, reproducible, sensitive, and easy to perform. Consequently, there is growing interest in the use of exhaled NO in the management of asthma and other pulmonary conditions. The purpose of this review is to promote a basic understanding of the physiologic actions of NO, measurement techniques, and ways that research findings might translate to future application in clinical practice. Specifically, the article will review the role of exhaled NO in regard to its historical background, mechanisms of action, measurement techniques, and implications for clinical practice and research.

KW - Asthma

KW - Chronic obstructive pulmonary diseases

KW - Exhaled gas analysis

KW - Lung inflammation

KW - Lung transplantation

KW - Nitric oxide

UR - http://www.scopus.com/inward/record.url?scp=33646461442&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33646461442&partnerID=8YFLogxK

U2 - 10.1016/j.chembiol.2005.12.011

DO - 10.1016/j.chembiol.2005.12.011

M3 - Article

VL - 7

SP - 241

EP - 255

JO - Biological Research for Nursing

JF - Biological Research for Nursing

SN - 1099-8004

IS - 4

ER -