Markedly prolonged theophylline half-life in liver failure

R. C. Baselt, Timothy E Albertson

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Theophylline toxicity developed within 48 hours of admission in a 63-year-old alcoholic male who presented with shortness of breath, edema, and lethargy. Using liquid chromatography, a serum theophylline half-life of 134 hours was observed following discontinuation of the drug. This report emphasizes the effect of hepatic disease on theopylline clearance and the need for frequent monitoring of plasma theopylline concentrations in cirrhotic patients.

Original languageEnglish (US)
Pages (from-to)62-63
Number of pages2
JournalJournal of Analytical Toxicology
Volume6
Issue number2
StatePublished - 1982

Fingerprint

Liquid chromatography
Liver Failure
Theophylline
Liver
half life
Half-Life
Toxicity
liquid chromatography
serum
drug
toxicity
Plasmas
plasma
Lethargy
Monitoring
monitoring
Liquid Chromatography
Dyspnea
Edema
Serum

ASJC Scopus subject areas

  • Analytical Chemistry
  • Health, Toxicology and Mutagenesis
  • Toxicology

Cite this

Markedly prolonged theophylline half-life in liver failure. / Baselt, R. C.; Albertson, Timothy E.

In: Journal of Analytical Toxicology, Vol. 6, No. 2, 1982, p. 62-63.

Research output: Contribution to journalArticle

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