Markedly prolonged theophylline half-life in liver failure

R. C. Baselt; Timothy E Albertson

Markedly prolonged theophylline half-life in liver failure

R. C. Baselt, Timothy E Albertson

Pulmonary, Critical Care, and Sleep Medicine

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Theophylline toxicity developed within 48 hours of admission in a 63-year-old alcoholic male who presented with shortness of breath, edema, and lethargy. Using liquid chromatography, a serum theophylline half-life of 134 hours was observed following discontinuation of the drug. This report emphasizes the effect of hepatic disease on theopylline clearance and the need for frequent monitoring of plasma theopylline concentrations in cirrhotic patients.

Original language	English (US)
Pages (from-to)	62-63
Number of pages	2
Journal	Journal of Analytical Toxicology
Volume	6
Issue number	2
State	Published - 1982

ASJC Scopus subject areas

Analytical Chemistry
Health, Toxicology and Mutagenesis
Toxicology

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title = "Markedly prolonged theophylline half-life in liver failure",

abstract = "Theophylline toxicity developed within 48 hours of admission in a 63-year-old alcoholic male who presented with shortness of breath, edema, and lethargy. Using liquid chromatography, a serum theophylline half-life of 134 hours was observed following discontinuation of the drug. This report emphasizes the effect of hepatic disease on theopylline clearance and the need for frequent monitoring of plasma theopylline concentrations in cirrhotic patients.",

author = "Baselt, {R. C.} and Albertson, {Timothy E}",

year = "1982",

language = "English (US)",

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journal = "Journal of Analytical Toxicology",

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T1 - Markedly prolonged theophylline half-life in liver failure

AU - Baselt, R. C.

AU - Albertson, Timothy E

PY - 1982

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N2 - Theophylline toxicity developed within 48 hours of admission in a 63-year-old alcoholic male who presented with shortness of breath, edema, and lethargy. Using liquid chromatography, a serum theophylline half-life of 134 hours was observed following discontinuation of the drug. This report emphasizes the effect of hepatic disease on theopylline clearance and the need for frequent monitoring of plasma theopylline concentrations in cirrhotic patients.

AB - Theophylline toxicity developed within 48 hours of admission in a 63-year-old alcoholic male who presented with shortness of breath, edema, and lethargy. Using liquid chromatography, a serum theophylline half-life of 134 hours was observed following discontinuation of the drug. This report emphasizes the effect of hepatic disease on theopylline clearance and the need for frequent monitoring of plasma theopylline concentrations in cirrhotic patients.

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