Abstract
Theophylline toxicity developed within 48 hours of admission in a 63-year-old alcoholic male who presented with shortness of breath, edema, and lethargy. Using liquid chromatography, a serum theophylline half-life of 134 hours was observed following discontinuation of the drug. This report emphasizes the effect of hepatic disease on theopylline clearance and the need for frequent monitoring of plasma theopylline concentrations in cirrhotic patients.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 62-63 |
| Number of pages | 2 |
| Journal | Journal of Analytical Toxicology |
| Volume | 6 |
| Issue number | 2 |
| State | Published - 1982 |
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ASJC Scopus subject areas
- Analytical Chemistry
- Health, Toxicology and Mutagenesis
- Toxicology
Cite this
Markedly prolonged theophylline half-life in liver failure. / Baselt, R. C.; Albertson, Timothy E.
In: Journal of Analytical Toxicology, Vol. 6, No. 2, 1982, p. 62-63.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Markedly prolonged theophylline half-life in liver failure
AU - Baselt, R. C.
AU - Albertson, Timothy E
PY - 1982
Y1 - 1982
N2 - Theophylline toxicity developed within 48 hours of admission in a 63-year-old alcoholic male who presented with shortness of breath, edema, and lethargy. Using liquid chromatography, a serum theophylline half-life of 134 hours was observed following discontinuation of the drug. This report emphasizes the effect of hepatic disease on theopylline clearance and the need for frequent monitoring of plasma theopylline concentrations in cirrhotic patients.
AB - Theophylline toxicity developed within 48 hours of admission in a 63-year-old alcoholic male who presented with shortness of breath, edema, and lethargy. Using liquid chromatography, a serum theophylline half-life of 134 hours was observed following discontinuation of the drug. This report emphasizes the effect of hepatic disease on theopylline clearance and the need for frequent monitoring of plasma theopylline concentrations in cirrhotic patients.
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UR - http://www.scopus.com/inward/citedby.url?scp=0020026543&partnerID=8YFLogxK
M3 - Article
C2 - 7098449
AN - SCOPUS:0020026543
VL - 6
SP - 62
EP - 63
JO - Journal of Analytical Toxicology
JF - Journal of Analytical Toxicology
SN - 0146-4760
IS - 2
ER -