Markedly increased central corneal thickness: An unrecognized finding in congenital aniridia

James D Brandt, Lourdes A. Casuso, Donald L. Budenz

Research output: Contribution to journalArticlepeer-review

67 Scopus citations


PURPOSE: To describe central corneal thickness among patients diagnosed with congenital aniridia. DESIGN: Prospective noninterventional case series. METHODS: We identified patients carrying the clinical diagnosis of congenital aniridia and performed complete ophthalmic examinations. Eyes with known corneal pathology were excluded. Central corneal thickness was determined as the mean of five measurements per eye, acquired by matching ultrasonic pachymeters at two clinical sites. RESULTS: Seventeen patients were identified at two sites; 32 eyes qualified for inclusion. The average central corneal thickness of the qualifying eyes was 631.6 ± 50.8 μM. CONCLUSION: Markedly increased central corneal thickness appears to be a previously unrecognized aspect of congenital aniridia. This may lead to incorrect estimates of intraocular pressure by applanation techniques and highlights the importance of monitoring patients with aniridia for the development of glaucoma through regular gonioscopy and optic nerve examination.

Original languageEnglish (US)
Pages (from-to)348-350
Number of pages3
JournalAmerican Journal of Ophthalmology
Issue number2
StatePublished - Feb 2004

ASJC Scopus subject areas

  • Ophthalmology


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