Marked elevation of serum lipoprotein (a) concentration in preeclamptic women at 3 months postpartum

D. Lasser, S. Chrisomalis, D. Heller, Lars Berglund

Research output: Contribution to journalArticle

Abstract

OBJECTIVE: To assess fulure cardiovascular disease risk in women who developed preeclamp.sia by measuring serum lipoprotein (a) [I,p(a)] concentrations at 3 months posiparlum. STUDY DESIGN: Prospective study of a cohort of 10 preecUunptic women at 3 months postpartum and matched pooled normal control women. Diagnosis of preeclampsia followed AGOG criteria. Index patients had no oilier medical conditions. Patients underwent routine medical evaluations postpartum. Mean .serum values were compared using the Student's T test. RESULTS: Ten women were examined at 3 months posipartum. All were ovulatorv and non-lactaimg. All had normal blood pressure and physical exams. None were taking medications. Half exceeded their ideal body weight bv more than 10%. The risk threshold for cardiovascular risk is wideh considered to be 30 mg/dl in adults. Mean serum Lp(a) was 64.03 mg/dl ±34.12 compared with 24.47 mg/dl ±12.89 in controls (p < 0.01). Of note, 7/10 patients had values exceeding 30 mg/dl (range: 21.9-111 mg/dl) and 4/10 had values beyond the 95th percentile of normal controls. CONCLUSIONS: Our findings suggest lhai women who develop preeclampsia are at risk for iutnre atherosclerotic heart disease as reflected by abnormal postpartum serum I.p(a) serum concentrations.

Original languageEnglish (US)
JournalActa Diabetologica Latina
Volume176
Issue number1 PART II
StatePublished - 1997
Externally publishedYes

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

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