Abstract
Experimental data support multiple roles for fatty acids in colorectal carcinogenesis. We examined dietary fatty acids and incidence of colorectal cancer, and evaluated effect modification by sex and stage of disease among a population-based cohort of 61,321 Singapore Chinese that was established between 1993 and 1998. As of December 31, 2005, 961 incident colorectal cancers were diagnosed. Presented hazard ratios (HRs) are for highest versus lowest quartiles with adjustment for potential confounders. Among women, we observed a dose-dependent, positive association between saturated fat and localized colorectal cancer (Dukes A or B) [(HR = 1.69, 95% confidence interval (CI) = 1.08-2.63, p for trend = 0.01)]. No such associations were noted in men (p for interaction by sex = 0.04). Marine n-3 polyunsaturated fatty acid (PUFA) intake was positively associated with advanced disease (Dukes C or D) (HR = 1.33, 95% CI = 1.05-1.70, p for trend = 0.01), regardless of sex. The association with marine n-3 PUFAs was strongest among those with the shortest (≤5 years) duration of follow-up (HR = 1.49, 95% CI = 1.00-2.21, p for trend = 0.04). In contrast, we observed a small, albeit imprecise, inverse association with marine n-3 PUFAs for localized colorectal cancer among those with the longest duration of follow-up (>10 years) (HR = 0.62, 95% CI = 0.29-1.34, p for trend = 0.55). Our findings suggest that subtypes of fatty acids may differentially influence risk of colorectal cancer of a specified stage.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 678-686 |
| Number of pages | 9 |
| Journal | International Journal of Cancer |
| Volume | 124 |
| Issue number | 3 |
| DOIs | |
| State | Published - Feb 1 2009 |
Fingerprint
Keywords
- Colorectal cancer
- Dietary fat
- Epidemiology
- Marine n-3 polyunsaturated fatty acids
- Saturated fatty acids
ASJC Scopus subject areas
- Cancer Research
- Oncology
- Medicine(all)
Cite this
Marine n-3 and saturated fatty acids in relation to risk of colorectal cancer in Singapore Chinese : A prospective study. / Butler, Lesley M.; Wang, Renwei; Koh, Woon Puay; Stern, Mariana C.; Yuan, Jian Min; Yu, Mimi C.
In: International Journal of Cancer, Vol. 124, No. 3, 01.02.2009, p. 678-686.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Marine n-3 and saturated fatty acids in relation to risk of colorectal cancer in Singapore Chinese
T2 - A prospective study
AU - Butler, Lesley M.
AU - Wang, Renwei
AU - Koh, Woon Puay
AU - Stern, Mariana C.
AU - Yuan, Jian Min
AU - Yu, Mimi C.
PY - 2009/2/1
Y1 - 2009/2/1
N2 - Experimental data support multiple roles for fatty acids in colorectal carcinogenesis. We examined dietary fatty acids and incidence of colorectal cancer, and evaluated effect modification by sex and stage of disease among a population-based cohort of 61,321 Singapore Chinese that was established between 1993 and 1998. As of December 31, 2005, 961 incident colorectal cancers were diagnosed. Presented hazard ratios (HRs) are for highest versus lowest quartiles with adjustment for potential confounders. Among women, we observed a dose-dependent, positive association between saturated fat and localized colorectal cancer (Dukes A or B) [(HR = 1.69, 95% confidence interval (CI) = 1.08-2.63, p for trend = 0.01)]. No such associations were noted in men (p for interaction by sex = 0.04). Marine n-3 polyunsaturated fatty acid (PUFA) intake was positively associated with advanced disease (Dukes C or D) (HR = 1.33, 95% CI = 1.05-1.70, p for trend = 0.01), regardless of sex. The association with marine n-3 PUFAs was strongest among those with the shortest (≤5 years) duration of follow-up (HR = 1.49, 95% CI = 1.00-2.21, p for trend = 0.04). In contrast, we observed a small, albeit imprecise, inverse association with marine n-3 PUFAs for localized colorectal cancer among those with the longest duration of follow-up (>10 years) (HR = 0.62, 95% CI = 0.29-1.34, p for trend = 0.55). Our findings suggest that subtypes of fatty acids may differentially influence risk of colorectal cancer of a specified stage.
AB - Experimental data support multiple roles for fatty acids in colorectal carcinogenesis. We examined dietary fatty acids and incidence of colorectal cancer, and evaluated effect modification by sex and stage of disease among a population-based cohort of 61,321 Singapore Chinese that was established between 1993 and 1998. As of December 31, 2005, 961 incident colorectal cancers were diagnosed. Presented hazard ratios (HRs) are for highest versus lowest quartiles with adjustment for potential confounders. Among women, we observed a dose-dependent, positive association between saturated fat and localized colorectal cancer (Dukes A or B) [(HR = 1.69, 95% confidence interval (CI) = 1.08-2.63, p for trend = 0.01)]. No such associations were noted in men (p for interaction by sex = 0.04). Marine n-3 polyunsaturated fatty acid (PUFA) intake was positively associated with advanced disease (Dukes C or D) (HR = 1.33, 95% CI = 1.05-1.70, p for trend = 0.01), regardless of sex. The association with marine n-3 PUFAs was strongest among those with the shortest (≤5 years) duration of follow-up (HR = 1.49, 95% CI = 1.00-2.21, p for trend = 0.04). In contrast, we observed a small, albeit imprecise, inverse association with marine n-3 PUFAs for localized colorectal cancer among those with the longest duration of follow-up (>10 years) (HR = 0.62, 95% CI = 0.29-1.34, p for trend = 0.55). Our findings suggest that subtypes of fatty acids may differentially influence risk of colorectal cancer of a specified stage.
KW - Colorectal cancer
KW - Dietary fat
KW - Epidemiology
KW - Marine n-3 polyunsaturated fatty acids
KW - Saturated fatty acids
UR - http://www.scopus.com/inward/record.url?scp=58149303288&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=58149303288&partnerID=8YFLogxK
U2 - 10.1002/ijc.23950
DO - 10.1002/ijc.23950
M3 - Article
C2 - 18973226
AN - SCOPUS:58149303288
VL - 124
SP - 678
EP - 686
JO - International Journal of Cancer
JF - International Journal of Cancer
SN - 0020-7136
IS - 3
ER -