Marek's disease vaccines: Current status, and strategies for improvement and development of vector vaccines

Sanjay M. Reddy, Yoshihiro Izumiya, Blanca Lupiani

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Marek's disease (MD) is a lymphoproliferative viral disease of chickens, which has been controlled through vaccination since 1969. MD vaccines protect against tumors but do not provide sterilizing immunity, and thus it is generally believed that their use has contributed to increase virulence of field strains with the ability to cause MD in vaccinated chickens. Traditional methods of developing vaccines, like cell culture attenuation, have proved unsuccessful for the development of improved vaccines to protect against highly virulent MD virus (MDV) field strains. With the advent of recombinant DNA technology, it is now possible to study MDV gene function and develop rational vaccines that protect against highly pathogenic strains. In addition, the long term protection conferred by MD vaccines, their excellent safety profile, their efficacy when administered early (at hatch or . in ovo), and their ability to overcome maternal antibodies, has made MDV an excellent candidate vector to protect not only against MD but also against other important viral poultry diseases. In this review we will discuss the current status of MD vaccines and their use as vector vaccines to control important viral poultry diseases.

Original languageEnglish (US)
JournalVeterinary Microbiology
DOIs
StateAccepted/In press - Oct 5 2016

Fingerprint

Marek Disease Vaccines
Marek Disease
vector vaccines
Marek disease
Virus Diseases
Vaccines
Poultry Diseases
vaccines
poultry diseases
Viruses
Chickens
Recombinant DNA
Virulence
Immunity
Mardivirus
viruses
Vaccination
recombinant DNA
maternal immunity
Cell Culture Techniques

Keywords

  • Chicken
  • Herpesvirus
  • Marek's disease
  • Recombinant
  • Vaccine
  • Vector

ASJC Scopus subject areas

  • Microbiology
  • veterinary(all)

Cite this

Marek's disease vaccines : Current status, and strategies for improvement and development of vector vaccines. / Reddy, Sanjay M.; Izumiya, Yoshihiro; Lupiani, Blanca.

In: Veterinary Microbiology, 05.10.2016.

Research output: Contribution to journalArticle

@article{0e0b740da92b4f4888fe600d7a18e499,
title = "Marek's disease vaccines: Current status, and strategies for improvement and development of vector vaccines",
abstract = "Marek's disease (MD) is a lymphoproliferative viral disease of chickens, which has been controlled through vaccination since 1969. MD vaccines protect against tumors but do not provide sterilizing immunity, and thus it is generally believed that their use has contributed to increase virulence of field strains with the ability to cause MD in vaccinated chickens. Traditional methods of developing vaccines, like cell culture attenuation, have proved unsuccessful for the development of improved vaccines to protect against highly virulent MD virus (MDV) field strains. With the advent of recombinant DNA technology, it is now possible to study MDV gene function and develop rational vaccines that protect against highly pathogenic strains. In addition, the long term protection conferred by MD vaccines, their excellent safety profile, their efficacy when administered early (at hatch or . in ovo), and their ability to overcome maternal antibodies, has made MDV an excellent candidate vector to protect not only against MD but also against other important viral poultry diseases. In this review we will discuss the current status of MD vaccines and their use as vector vaccines to control important viral poultry diseases.",
keywords = "Chicken, Herpesvirus, Marek's disease, Recombinant, Vaccine, Vector",
author = "Reddy, {Sanjay M.} and Yoshihiro Izumiya and Blanca Lupiani",
year = "2016",
month = "10",
day = "5",
doi = "10.1016/j.vetmic.2016.11.024",
language = "English (US)",
journal = "Veterinary Microbiology",
issn = "0378-1135",
publisher = "Elsevier",

}

TY - JOUR

T1 - Marek's disease vaccines

T2 - Current status, and strategies for improvement and development of vector vaccines

AU - Reddy, Sanjay M.

AU - Izumiya, Yoshihiro

AU - Lupiani, Blanca

PY - 2016/10/5

Y1 - 2016/10/5

N2 - Marek's disease (MD) is a lymphoproliferative viral disease of chickens, which has been controlled through vaccination since 1969. MD vaccines protect against tumors but do not provide sterilizing immunity, and thus it is generally believed that their use has contributed to increase virulence of field strains with the ability to cause MD in vaccinated chickens. Traditional methods of developing vaccines, like cell culture attenuation, have proved unsuccessful for the development of improved vaccines to protect against highly virulent MD virus (MDV) field strains. With the advent of recombinant DNA technology, it is now possible to study MDV gene function and develop rational vaccines that protect against highly pathogenic strains. In addition, the long term protection conferred by MD vaccines, their excellent safety profile, their efficacy when administered early (at hatch or . in ovo), and their ability to overcome maternal antibodies, has made MDV an excellent candidate vector to protect not only against MD but also against other important viral poultry diseases. In this review we will discuss the current status of MD vaccines and their use as vector vaccines to control important viral poultry diseases.

AB - Marek's disease (MD) is a lymphoproliferative viral disease of chickens, which has been controlled through vaccination since 1969. MD vaccines protect against tumors but do not provide sterilizing immunity, and thus it is generally believed that their use has contributed to increase virulence of field strains with the ability to cause MD in vaccinated chickens. Traditional methods of developing vaccines, like cell culture attenuation, have proved unsuccessful for the development of improved vaccines to protect against highly virulent MD virus (MDV) field strains. With the advent of recombinant DNA technology, it is now possible to study MDV gene function and develop rational vaccines that protect against highly pathogenic strains. In addition, the long term protection conferred by MD vaccines, their excellent safety profile, their efficacy when administered early (at hatch or . in ovo), and their ability to overcome maternal antibodies, has made MDV an excellent candidate vector to protect not only against MD but also against other important viral poultry diseases. In this review we will discuss the current status of MD vaccines and their use as vector vaccines to control important viral poultry diseases.

KW - Chicken

KW - Herpesvirus

KW - Marek's disease

KW - Recombinant

KW - Vaccine

KW - Vector

UR - http://www.scopus.com/inward/record.url?scp=85009284729&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85009284729&partnerID=8YFLogxK

U2 - 10.1016/j.vetmic.2016.11.024

DO - 10.1016/j.vetmic.2016.11.024

M3 - Article

C2 - 28038868

AN - SCOPUS:85009284729

JO - Veterinary Microbiology

JF - Veterinary Microbiology

SN - 0378-1135

ER -