Abstract
Marek's disease (MD) is a lymphoproliferative viral disease of chickens, which has been controlled through vaccination since 1969. MD vaccines protect against tumors but do not provide sterilizing immunity, and thus it is generally believed that their use has contributed to increase virulence of field strains with the ability to cause MD in vaccinated chickens. Traditional methods of developing vaccines, like cell culture attenuation, have proved unsuccessful for the development of improved vaccines to protect against highly virulent MD virus (MDV) field strains. With the advent of recombinant DNA technology, it is now possible to study MDV gene function and develop rational vaccines that protect against highly pathogenic strains. In addition, the long term protection conferred by MD vaccines, their excellent safety profile, their efficacy when administered early (at hatch or . in ovo), and their ability to overcome maternal antibodies, has made MDV an excellent candidate vector to protect not only against MD but also against other important viral poultry diseases. In this review we will discuss the current status of MD vaccines and their use as vector vaccines to control important viral poultry diseases.
| Original language | English (US) |
|---|---|
| Journal | Veterinary Microbiology |
| DOIs | |
| State | Accepted/In press - Oct 5 2016 |
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Keywords
- Chicken
- Herpesvirus
- Marek's disease
- Recombinant
- Vaccine
- Vector
ASJC Scopus subject areas
- Microbiology
- veterinary(all)
Cite this
Marek's disease vaccines : Current status, and strategies for improvement and development of vector vaccines. / Reddy, Sanjay M.; Izumiya, Yoshihiro; Lupiani, Blanca.
In: Veterinary Microbiology, 05.10.2016.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Marek's disease vaccines
T2 - Current status, and strategies for improvement and development of vector vaccines
AU - Reddy, Sanjay M.
AU - Izumiya, Yoshihiro
AU - Lupiani, Blanca
PY - 2016/10/5
Y1 - 2016/10/5
N2 - Marek's disease (MD) is a lymphoproliferative viral disease of chickens, which has been controlled through vaccination since 1969. MD vaccines protect against tumors but do not provide sterilizing immunity, and thus it is generally believed that their use has contributed to increase virulence of field strains with the ability to cause MD in vaccinated chickens. Traditional methods of developing vaccines, like cell culture attenuation, have proved unsuccessful for the development of improved vaccines to protect against highly virulent MD virus (MDV) field strains. With the advent of recombinant DNA technology, it is now possible to study MDV gene function and develop rational vaccines that protect against highly pathogenic strains. In addition, the long term protection conferred by MD vaccines, their excellent safety profile, their efficacy when administered early (at hatch or . in ovo), and their ability to overcome maternal antibodies, has made MDV an excellent candidate vector to protect not only against MD but also against other important viral poultry diseases. In this review we will discuss the current status of MD vaccines and their use as vector vaccines to control important viral poultry diseases.
AB - Marek's disease (MD) is a lymphoproliferative viral disease of chickens, which has been controlled through vaccination since 1969. MD vaccines protect against tumors but do not provide sterilizing immunity, and thus it is generally believed that their use has contributed to increase virulence of field strains with the ability to cause MD in vaccinated chickens. Traditional methods of developing vaccines, like cell culture attenuation, have proved unsuccessful for the development of improved vaccines to protect against highly virulent MD virus (MDV) field strains. With the advent of recombinant DNA technology, it is now possible to study MDV gene function and develop rational vaccines that protect against highly pathogenic strains. In addition, the long term protection conferred by MD vaccines, their excellent safety profile, their efficacy when administered early (at hatch or . in ovo), and their ability to overcome maternal antibodies, has made MDV an excellent candidate vector to protect not only against MD but also against other important viral poultry diseases. In this review we will discuss the current status of MD vaccines and their use as vector vaccines to control important viral poultry diseases.
KW - Chicken
KW - Herpesvirus
KW - Marek's disease
KW - Recombinant
KW - Vaccine
KW - Vector
UR - http://www.scopus.com/inward/record.url?scp=85009284729&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85009284729&partnerID=8YFLogxK
U2 - 10.1016/j.vetmic.2016.11.024
DO - 10.1016/j.vetmic.2016.11.024
M3 - Article
C2 - 28038868
AN - SCOPUS:85009284729
JO - Veterinary Microbiology
JF - Veterinary Microbiology
SN - 0378-1135
ER -