Mapping ventricular changes related to dementia and mild cognitive impairment in a large community-based cohort

Owen T. Carmichael, Paul M. Thompson, Rebecca A. Dutton, Allen Lu, Sharon E. Lee, Jessica Y. Lee, Lewis H. Kuller, Oscar L. Lopez, Howard J. Aizenstein, Carolyn Cidis Meltzer, Yanxi Liu, Arthur W. Toga, James T. Becker

Research output: Chapter in Book/Report/Conference proceedingConference contribution

21 Scopus citations

Abstract

We present a fully-automated technique for visualizing localized cerebral ventricle shape differences between large clinical subject groups who have received a magnetic resonance (MR) image scan. The technique combines a robust, automated technique for ventricular segmentation with a 3D surface-based radial thickness mapping approach that allows spatially-localized statistical tests of relative shape differences between clinical groups. The technique is used to analyze localized ventricular expansion in Alzheimer's Disease (AD) and mild cognitive impairment (MCI) in a large cohort of community-dwelling elderly individuals (N=339). The resulting maps are the first to chart localized ventricular dilation in a cohort of this size. Besides showing patterns of ventricular expansion that may be consistent with the spatial progression of AD-related pathology, the maps reveal new information about localized ventricular atrophy that may have been overlooked to date. A detailed understanding of spatial atrophy patterns may be useful for early disease detection or for patient monitoring in drug trials.

Original languageEnglish (US)
Title of host publication2006 3rd IEEE International Symposium on Biomedical Imaging: From Nano to Macro - Proceedings
Pages315-318
Number of pages4
Volume2006
StatePublished - 2006
Event2006 3rd IEEE International Symposium on Biomedical Imaging: From Nano to Macro - Arlington, VA, United States
Duration: Apr 6 2006Apr 9 2006

Other

Other2006 3rd IEEE International Symposium on Biomedical Imaging: From Nano to Macro
CountryUnited States
CityArlington, VA
Period4/6/064/9/06

ASJC Scopus subject areas

  • Engineering(all)

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    Carmichael, O. T., Thompson, P. M., Dutton, R. A., Lu, A., Lee, S. E., Lee, J. Y., Kuller, L. H., Lopez, O. L., Aizenstein, H. J., Meltzer, C. C., Liu, Y., Toga, A. W., & Becker, J. T. (2006). Mapping ventricular changes related to dementia and mild cognitive impairment in a large community-based cohort. In 2006 3rd IEEE International Symposium on Biomedical Imaging: From Nano to Macro - Proceedings (Vol. 2006, pp. 315-318). [1624916]