Abstract
We present a fully-automated technique for visualizing localized cerebral ventricle shape differences between large clinical subject groups who have received a magnetic resonance (MR) image scan. The technique combines a robust, automated technique for ventricular segmentation with a 3D surface-based radial thickness mapping approach that allows spatially-localized statistical tests of relative shape differences between clinical groups. The technique is used to analyze localized ventricular expansion in Alzheimer's Disease (AD) and mild cognitive impairment (MCI) in a large cohort of community-dwelling elderly individuals (N=339). The resulting maps are the first to chart localized ventricular dilation in a cohort of this size. Besides showing patterns of ventricular expansion that may be consistent with the spatial progression of AD-related pathology, the maps reveal new information about localized ventricular atrophy that may have been overlooked to date. A detailed understanding of spatial atrophy patterns may be useful for early disease detection or for patient monitoring in drug trials.
| Original language | English (US) |
|---|---|
| Title of host publication | 2006 3rd IEEE International Symposium on Biomedical Imaging: From Nano to Macro - Proceedings |
| Pages | 315-318 |
| Number of pages | 4 |
| Volume | 2006 |
| State | Published - 2006 |
| Event | 2006 3rd IEEE International Symposium on Biomedical Imaging: From Nano to Macro - Arlington, VA, United States Duration: Apr 6 2006 → Apr 9 2006 |
Other
| Other | 2006 3rd IEEE International Symposium on Biomedical Imaging: From Nano to Macro |
|---|---|
| Country | United States |
| City | Arlington, VA |
| Period | 4/6/06 → 4/9/06 |
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ASJC Scopus subject areas
- Engineering(all)
Cite this
Mapping ventricular changes related to dementia and mild cognitive impairment in a large community-based cohort. / Carmichael, Owen T.; Thompson, Paul M.; Dutton, Rebecca A.; Lu, Allen; Lee, Sharon E.; Lee, Jessica Y.; Kuller, Lewis H.; Lopez, Oscar L.; Aizenstein, Howard J.; Meltzer, Carolyn Cidis; Liu, Yanxi; Toga, Arthur W.; Becker, James T.
2006 3rd IEEE International Symposium on Biomedical Imaging: From Nano to Macro - Proceedings. Vol. 2006 2006. p. 315-318 1624916.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - Mapping ventricular changes related to dementia and mild cognitive impairment in a large community-based cohort
AU - Carmichael, Owen T.
AU - Thompson, Paul M.
AU - Dutton, Rebecca A.
AU - Lu, Allen
AU - Lee, Sharon E.
AU - Lee, Jessica Y.
AU - Kuller, Lewis H.
AU - Lopez, Oscar L.
AU - Aizenstein, Howard J.
AU - Meltzer, Carolyn Cidis
AU - Liu, Yanxi
AU - Toga, Arthur W.
AU - Becker, James T.
PY - 2006
Y1 - 2006
N2 - We present a fully-automated technique for visualizing localized cerebral ventricle shape differences between large clinical subject groups who have received a magnetic resonance (MR) image scan. The technique combines a robust, automated technique for ventricular segmentation with a 3D surface-based radial thickness mapping approach that allows spatially-localized statistical tests of relative shape differences between clinical groups. The technique is used to analyze localized ventricular expansion in Alzheimer's Disease (AD) and mild cognitive impairment (MCI) in a large cohort of community-dwelling elderly individuals (N=339). The resulting maps are the first to chart localized ventricular dilation in a cohort of this size. Besides showing patterns of ventricular expansion that may be consistent with the spatial progression of AD-related pathology, the maps reveal new information about localized ventricular atrophy that may have been overlooked to date. A detailed understanding of spatial atrophy patterns may be useful for early disease detection or for patient monitoring in drug trials.
AB - We present a fully-automated technique for visualizing localized cerebral ventricle shape differences between large clinical subject groups who have received a magnetic resonance (MR) image scan. The technique combines a robust, automated technique for ventricular segmentation with a 3D surface-based radial thickness mapping approach that allows spatially-localized statistical tests of relative shape differences between clinical groups. The technique is used to analyze localized ventricular expansion in Alzheimer's Disease (AD) and mild cognitive impairment (MCI) in a large cohort of community-dwelling elderly individuals (N=339). The resulting maps are the first to chart localized ventricular dilation in a cohort of this size. Besides showing patterns of ventricular expansion that may be consistent with the spatial progression of AD-related pathology, the maps reveal new information about localized ventricular atrophy that may have been overlooked to date. A detailed understanding of spatial atrophy patterns may be useful for early disease detection or for patient monitoring in drug trials.
UR - http://www.scopus.com/inward/record.url?scp=33750935303&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33750935303&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:33750935303
SN - 0780395778
SN - 9780780395770
VL - 2006
SP - 315
EP - 318
BT - 2006 3rd IEEE International Symposium on Biomedical Imaging: From Nano to Macro - Proceedings
ER -