Abstract
We present a fully-automated technique for visualizing localized cerebral ventricle shape differences between large clinical subject groups who have received a magnetic resonance (MR) image scan. The technique combines a robust, automated technique for ventricular segmentation with a 3D surface-based radial thickness mapping approach that allows spatially-localized statistical tests of relative shape differences between clinical groups. The technique is used to analyze localized ventricular expansion in Alzheimer's Disease (AD) and mild cognitive impairment (MCI) in a large cohort of community-dwelling elderly individuals (N=339). The resulting maps are the first to chart localized ventricular dilation in a cohort of this size. Besides showing patterns of ventricular expansion that may be consistent with the spatial progression of AD-related pathology, the maps reveal new information about localized ventricular atrophy that may have been overlooked to date. A detailed understanding of spatial atrophy patterns may be useful for early disease detection or for patient monitoring in drug trials.
Original language | English (US) |
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Title of host publication | 2006 3rd IEEE International Symposium on Biomedical Imaging: From Nano to Macro - Proceedings |
Pages | 315-318 |
Number of pages | 4 |
Volume | 2006 |
State | Published - 2006 |
Event | 2006 3rd IEEE International Symposium on Biomedical Imaging: From Nano to Macro - Arlington, VA, United States Duration: Apr 6 2006 → Apr 9 2006 |
Other
Other | 2006 3rd IEEE International Symposium on Biomedical Imaging: From Nano to Macro |
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Country/Territory | United States |
City | Arlington, VA |
Period | 4/6/06 → 4/9/06 |
ASJC Scopus subject areas
- Engineering(all)