Mapping ventricular changes related to dementia and mild cognitive impairment in a large community-based cohort

Owen T. Carmichael; Paul M. Thompson; Rebecca A. Dutton; Allen Lu; Sharon E. Lee; Jessica Y. Lee; Lewis H. Kuller; Oscar L. Lopez; Howard J. Aizenstein; Carolyn Cidis Meltzer; Yanxi Liu; Arthur W. Toga; James T. Becker

Mapping ventricular changes related to dementia and mild cognitive impairment in a large community-based cohort

Owen T. Carmichael, Paul M. Thompson, Rebecca A. Dutton, Allen Lu, Sharon E. Lee, Jessica Y. Lee, Lewis H. Kuller, Oscar L. Lopez, Howard J. Aizenstein, Carolyn Cidis Meltzer, Yanxi Liu, Arthur W. Toga, James T. Becker

Neurology

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

21 Scopus citations

Abstract

We present a fully-automated technique for visualizing localized cerebral ventricle shape differences between large clinical subject groups who have received a magnetic resonance (MR) image scan. The technique combines a robust, automated technique for ventricular segmentation with a 3D surface-based radial thickness mapping approach that allows spatially-localized statistical tests of relative shape differences between clinical groups. The technique is used to analyze localized ventricular expansion in Alzheimer's Disease (AD) and mild cognitive impairment (MCI) in a large cohort of community-dwelling elderly individuals (N=339). The resulting maps are the first to chart localized ventricular dilation in a cohort of this size. Besides showing patterns of ventricular expansion that may be consistent with the spatial progression of AD-related pathology, the maps reveal new information about localized ventricular atrophy that may have been overlooked to date. A detailed understanding of spatial atrophy patterns may be useful for early disease detection or for patient monitoring in drug trials.

Original language	English (US)
Title of host publication	2006 3rd IEEE International Symposium on Biomedical Imaging: From Nano to Macro - Proceedings
Pages	315-318
Number of pages	4
Volume	2006
State	Published - 2006
Event	2006 3rd IEEE International Symposium on Biomedical Imaging: From Nano to Macro - Arlington, VA, United States Duration: Apr 6 2006 → Apr 9 2006

Other

Other	2006 3rd IEEE International Symposium on Biomedical Imaging: From Nano to Macro
Country	United States
City	Arlington, VA
Period	4/6/06 → 4/9/06

ASJC Scopus subject areas

Engineering(all)

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Carmichael, O. T., Thompson, P. M., Dutton, R. A., Lu, A., Lee, S. E., Lee, J. Y., Kuller, L. H., Lopez, O. L., Aizenstein, H. J., Meltzer, C. C., Liu, Y., Toga, A. W., & Becker, J. T. (2006). Mapping ventricular changes related to dementia and mild cognitive impairment in a large community-based cohort. In 2006 3rd IEEE International Symposium on Biomedical Imaging: From Nano to Macro - Proceedings (Vol. 2006, pp. 315-318). [1624916]

Mapping ventricular changes related to dementia and mild cognitive impairment in a large community-based cohort. / Carmichael, Owen T.; Thompson, Paul M.; Dutton, Rebecca A.; Lu, Allen; Lee, Sharon E.; Lee, Jessica Y.; Kuller, Lewis H.; Lopez, Oscar L.; Aizenstein, Howard J.; Meltzer, Carolyn Cidis; Liu, Yanxi; Toga, Arthur W.; Becker, James T.

2006 3rd IEEE International Symposium on Biomedical Imaging: From Nano to Macro - Proceedings. Vol. 2006 2006. p. 315-318 1624916.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Carmichael, OT, Thompson, PM, Dutton, RA, Lu, A, Lee, SE, Lee, JY, Kuller, LH, Lopez, OL, Aizenstein, HJ, Meltzer, CC, Liu, Y, Toga, AW & Becker, JT 2006, Mapping ventricular changes related to dementia and mild cognitive impairment in a large community-based cohort. in 2006 3rd IEEE International Symposium on Biomedical Imaging: From Nano to Macro - Proceedings. vol. 2006, 1624916, pp. 315-318, 2006 3rd IEEE International Symposium on Biomedical Imaging: From Nano to Macro, Arlington, VA, United States, 4/6/06.

Carmichael, Owen T. ; Thompson, Paul M. ; Dutton, Rebecca A. ; Lu, Allen ; Lee, Sharon E. ; Lee, Jessica Y. ; Kuller, Lewis H. ; Lopez, Oscar L. ; Aizenstein, Howard J. ; Meltzer, Carolyn Cidis ; Liu, Yanxi ; Toga, Arthur W. ; Becker, James T. / Mapping ventricular changes related to dementia and mild cognitive impairment in a large community-based cohort. 2006 3rd IEEE International Symposium on Biomedical Imaging: From Nano to Macro - Proceedings. Vol. 2006 2006. pp. 315-318

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abstract = "We present a fully-automated technique for visualizing localized cerebral ventricle shape differences between large clinical subject groups who have received a magnetic resonance (MR) image scan. The technique combines a robust, automated technique for ventricular segmentation with a 3D surface-based radial thickness mapping approach that allows spatially-localized statistical tests of relative shape differences between clinical groups. The technique is used to analyze localized ventricular expansion in Alzheimer's Disease (AD) and mild cognitive impairment (MCI) in a large cohort of community-dwelling elderly individuals (N=339). The resulting maps are the first to chart localized ventricular dilation in a cohort of this size. Besides showing patterns of ventricular expansion that may be consistent with the spatial progression of AD-related pathology, the maps reveal new information about localized ventricular atrophy that may have been overlooked to date. A detailed understanding of spatial atrophy patterns may be useful for early disease detection or for patient monitoring in drug trials.",

author = "Carmichael, {Owen T.} and Thompson, {Paul M.} and Dutton, {Rebecca A.} and Allen Lu and Lee, {Sharon E.} and Lee, {Jessica Y.} and Kuller, {Lewis H.} and Lopez, {Oscar L.} and Aizenstein, {Howard J.} and Meltzer, {Carolyn Cidis} and Yanxi Liu and Toga, {Arthur W.} and Becker, {James T.}",

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AU - Lu, Allen

AU - Lee, Sharon E.

AU - Lee, Jessica Y.

AU - Kuller, Lewis H.

AU - Lopez, Oscar L.

AU - Aizenstein, Howard J.

AU - Meltzer, Carolyn Cidis

AU - Liu, Yanxi

AU - Toga, Arthur W.

AU - Becker, James T.

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AB - We present a fully-automated technique for visualizing localized cerebral ventricle shape differences between large clinical subject groups who have received a magnetic resonance (MR) image scan. The technique combines a robust, automated technique for ventricular segmentation with a 3D surface-based radial thickness mapping approach that allows spatially-localized statistical tests of relative shape differences between clinical groups. The technique is used to analyze localized ventricular expansion in Alzheimer's Disease (AD) and mild cognitive impairment (MCI) in a large cohort of community-dwelling elderly individuals (N=339). The resulting maps are the first to chart localized ventricular dilation in a cohort of this size. Besides showing patterns of ventricular expansion that may be consistent with the spatial progression of AD-related pathology, the maps reveal new information about localized ventricular atrophy that may have been overlooked to date. A detailed understanding of spatial atrophy patterns may be useful for early disease detection or for patient monitoring in drug trials.

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